NARS2 Antibodies, cDNA Clones Research Reagents

NARS2 (Asparaginyl-TRNA Synthetase 2, Mitochondrial, also known as SLM5; asnRS; DFNB94), located on 11q14.1, is a Protein Coding gene. This gene encodes a putative member of the class II family of aminoacyl-tRNA synthetases and is expected to function as a dimer. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of asparagine to tRNA molecules. The deduced 477-amino acid protein has an N-terminal mitochondrial targeting signal with a predicted cleavage site after residue 14.

NARS2 Antibody (1)

    NARS2 cDNA Clone (30)

    NM_001243251.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_153591.4

    クローニングベクター cDNA 製品

    In lentiviral vector

    NARS2 qPCR Primer (1)

    NARS2 の背景知識

    NARS2 (Asparaginyl-TRNA Synthetase 2, Mitochondrial) is a Protein Coding gene. The NARS2 gene, located on 11q14.1, is conserved in chimpanzee, Rhesus monkey, dog, and cow, etc. NARS2 belongs to the class-II aminoacyl-tRNA synthetase family. This gene encodes a putative member of the class II family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. This protein is encoded by the nuclear genome but is likely to be imported to the mitochondrion where it is thought to catalyze the ligation of asparagine to tRNA molecules. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency 24 (COXPD24). NARS2 mutations cause various clinical phenotypes, including non-syndromic hearing loss, Leigh syndrome, intellectual disability with epilepsy, and severe myopathy.

    NARS2 の参考文献

    • Mizuguchi T, et al. (2017) Erratum: Pars2 and nars2 mutations in infantile-onset neurodegenerative disorder. J Hum Genet 62 (5): 587.
    • Liu G, et al. (2018) Alzheimer's disease risk variant rs2373115 regulates gab2 and nars2 expression in human brain tissues. J Mol Neurosci 66 (1): 37-43.
    • Bruwer Z, et al. (2018) Inborn errors of metabolism in a cohort of pregnancies with non-immune hydrops fetalis: A single center experience. J Perinat Med 46 (9): 968-974.

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