NAB2 Antibodies, cDNA Clones Research Reagents

NAB2 (NGFI-A Binding Protein 2, also known as MADER), located on 12q13.3, is a Protein Coding gene. The encoded protein acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. NAB2 is a 525-amino acid protein that differs from mouse Nab2 by 25 amino acids. Mouse Nab2 shows high homology to mouse Nab1 within 2 domains of approximately 100 amino acids each, called the NCD1 and NCD2. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deacetylase (NuRD) complex.

NAB2 Antibody (1)

    NAB2 cDNA Clone (15)


    クローニングベクター cDNA 製品

    In lentiviral vector

    NAB2 qPCR Primer (1)

    NAB2 の背景知識

    Nab2 is constructed from an N-terminal PWI-fold domain, followed by QQQP and RGG motifs and then seven CCCH Zn fingers. The nuclear pore-associated proteins Gfd1 and Mlp1 bind to opposite sides of the Nab2 N-terminal domain and function in the nuclear export of mRNA, whereas the Zn fingers bind to A-rich regions of mature transcripts and function to regulate poly(A) tail length as well as mRNA compaction before nuclear export. NGF1-A-binding protein 2 (Nab2) is a conserved transcriptional cofactor that directly binds to Egr-1 and positively or negatively modulates Egr-1 target gene transcription. Nab2 is a novel endogenous negative regulator of Egr-1-dependent TGF-beta signaling responsible for setting the intensity of fibrotic responses. Defective Nab2 expression or function in dermal fibroblasts might play a role in persistent fibrotic responses in scleroderma. Mutations in the gene encoding the human Nab2 orthologue ZC3H14 and cause intellectual disability.

    NAB2 の参考文献

    • Oberson A, et al. (2018) Nab2 is a novel immune stimulator of mda-5 that promotes a strong type i interferon response. Oncotarget 9 (5): 5641-5651.
    • Fasken MB, et al. (2019) Structure-function relationships in the nab2 polyadenosine-rna binding zn finger protein family. Protein Sci 28 (3): 513-523.
    • Bhattacharyya S, et al. (2009) The transcriptional cofactor nab2 is induced by tgf-beta and suppresses fibroblast activation: Physiological roles and impaired expression in scleroderma. PLoS One 4 (10): e7620.

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