Naa50 (also known as San) has previously been shown to play a role in sister-chromatid cohesion in metazoans. The gene separation anxiety (san) encodes Naa50/San, an N-terminal acetyltransferase required for chromosome segregation during mitosis. Naa50/San N-terminally acetylates the nascent Scc1 polypeptide, and that this co-translational modification is subsequently required for the establishment and/or maintenance of sister chromatid cohesion. NAA50, an interactor of EDR1, plays an important role in regulating the tradeoff between plant growth and defense. Plants lacking NAA50 display severe developmental defects as well as induced stress responses. Reduction of NAA50 expression results in arrested stem and root growth as well as senescence. The loss of NAA50 results in constitutive ER stress signaling, indicating that NAA50 may be required for the suppression of ER stress.