NAA50 Antibodies, cDNA Clones Research Reagents

NAA50 (N-Alpha-Acetyltransferase 50, NatE Catalytic Subunit, also known as SAN; MAK3; NAT5; NAT13; NAT5P; NAT13P; hNaa50p), located on 3q13.31, is a Protein Coding gene. NAA50, an interactor of EDR1, plays an important role in regulating the tradeoff between plant growth and defense. NAA50 belongs to the acetyltransferase family, GNAT subfamily. The deduced 169-amino acid protein contains a motif essential for acetyl-CoA binding, and it has a calculated molecular mass of 19.4 kD. NAT13 shares 25% identity with yeast Nat5 and 70% identity with the Drosophila homolog, San.

NAA50 Antibody (1)

    NAA50 cDNA Clone (15)

    BC012731

    クローニングベクター cDNA 製品

    In lentiviral vector

    NAA50 qPCR Primer (1)

    NAA50 の背景知識

    Naa50 (also known as San) has previously been shown to play a role in sister-chromatid cohesion in metazoans. The gene separation anxiety (san) encodes Naa50/San, an N-terminal acetyltransferase required for chromosome segregation during mitosis. Naa50/San N-terminally acetylates the nascent Scc1 polypeptide, and that this co-translational modification is subsequently required for the establishment and/or maintenance of sister chromatid cohesion. NAA50, an interactor of EDR1, plays an important role in regulating the tradeoff between plant growth and defense. Plants lacking NAA50 display severe developmental defects as well as induced stress responses. Reduction of NAA50 expression results in arrested stem and root growth as well as senescence. The loss of NAA50 results in constitutive ER stress signaling, indicating that NAA50 may be required for the suppression of ER stress.

    NAA50 の参考文献

    • Rong Z, et al. (2016) Opposing functions of the n-terminal acetyltransferases naa50 and nata in sister-chromatid cohesion. J Biol Chem 291 (36): 19079-19091.
    • Ribeiro AL, et al. (2016) Naa50/san-dependent n-terminal acetylation of scc1 is potentially important for sister chromatid cohesion. Sci Rep 6 39118.
    • Neubauer M, et al. (2020) Loss of the acetyltransferase naa50 induces endoplasmic reticulum stress and immune responses and suppresses growth. Plant Physiol 183 (4): 1838-1854.

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