NAA10/ARD1 Proteins, Antibodies, cDNA Clones Research Reagents

NAA10 (N-Alpha-Acetyltransferase 10, NatA Catalytic Subunit, also known as TE2; ARD1; NATD; ARD1A; ARD1P; OGDNS; hARD1; DXS707; MCOPS1), located on Xq28, is conserved in chimpanzee, dog, cow, mouse, rat, zebrafish, fruit fly, mosquito, C.elegans, and frog. The gene produces a 26459 Da protein composed of 235 amino acids. N-alpha-acetylation is among the most common post-translational protein modifications in eukaryotic cells. Diseases such as Ogden Syndrome and Microphthalmia, Syndromic 1 are associated with NAA10. The related pathways of NAA10 include Chromatin Regulation / Acetylation and Hypoxic and oxygen homeostasis regulation of HIF-1-alpha.

NAA10/ARD1 Protein (2)

    NAA10/ARD1 Antibody (6)

      NAA10/ARD1 cDNA Clone (15)

      BC000308

      クローニングベクター cDNA 製品

      In lentiviral vector

      NAA10/ARD1 qPCR Primer (1)

      NAA10/ARD1 Lysate (2)

        NAA10/ARD1 の背景知識

        ARD1 is a member of the 2-kDa ARF protein family. It is a multifunctional protein. ARD1 has an 18-kDa ADP-ribosylation factor (ARF) domain at the C-terminus (amino acids 43-574), and a 46-kDa N-terminal domain (amino acids 1-42). The C-terminal region of ARD1 may be involved in the formation of both ARD1-ARD1 and ARD1-NAT1 complexes. ARD1 and NAT1 genes are required for the expression of an N-terminal protein acetyltransferase. This activity is required for full repression of the silent mating-type locus HML, for sporulation, and for entry into G. Recombinant ARD1 (amino acids 1-574) or its RING finger domain (amino acids 1-11) produced polyubiquitylated proteins when incubated in vitro with a mammalian E1, an E2 enzyme, ATP, and ubiquitin.

        NAA10/ARD1 の参考文献

        • Tribioli C., et al.,(1994), Isolation of new genes in distal Xq28: transcriptional map and identification of a human homologue of the ARD1 N-acetyl transferase of Saccharomyces cerevisiae. Hum. Mol. Genet. 3:1061-1068.
        • Arnesen T., et al., (2005), Identification and characterization of the human ARD1-NATH protein acetyltransferase complex.Biochem. J. 386:433-443.
        • Ross M.T., et al.,(2005), The DNA sequence of the human X chromosome.Nature 434:325-337.

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