Myelin Oligodendrocyte Glycoprotein Proteins, Antibodies, cDNA Clones Research Reagents

All Myelin Oligodendrocyte Glycoprotein reagents are produced in house and quality controlled, including 7 Myelin Oligodendrocyte Glycoprotein Antibody, 27 Myelin Oligodendrocyte Glycoprotein Gene, 1 Myelin Oligodendrocyte Glycoprotein IP Kit, 2 Myelin Oligodendrocyte Glycoprotein Protein, 2 Myelin Oligodendrocyte Glycoprotein qPCR. All Myelin Oligodendrocyte Glycoprotein reagents are ready to use.

Myelin Oligodendrocyte Glycoprotein Protein (2)

    Myelin Oligodendrocyte Glycoprotein Antibody (7)

      Myelin Oligodendrocyte Glycoprotein cDNA Clone (27)

      NM_206809.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_206814.5

      In expression vector

      NM_010814.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      Myelin Oligodendrocyte Glycoprotein IP Kit (1)

      Myelin Oligodendrocyte Glycoprotein の背景知識

      Myelin oligodendrocyte glycoprotein (MOG) is a transmembrane protein belonging to immunoglobulin superfamily, and contains an Ig-like domain followed by two potential membrane-spanning regions. MOG is expressed only in the CNS with very low content (approximately .1% total proteins) in oligodendrogliocyte membrane. Three possible functions for MOG were suggested: (a) a cellular adhesive molecule, (b) a regulator of oligodendrocyte microtubule stability, and (c) a mediator of interactions between myelin and the immune system, in particular, the complement cascade. A direct interaction might exist between the membrane-associated regions of MOG and the myelin-specific glycolipid galactocerebroside (Gal-C), and such an interaction may have important consequences regarding the membrane topology and function of both molecules. It is considered that MOG is an autoantigen capable to produce a demyelinating multiple sclerosis-like disease in experimental animals.

      Myelin Oligodendrocyte Glycoprotein の参考文献

      • Chekhonin VP, et al. (2003) Myelin oligodendrogliocyte glycoprotein: the structure, functions, role in pathogenesis of demyelinating disorders. Biomed Khim. 49(5): 411-23.
      • Hilton AA, et al. (1995) Characterization of cDNA and Genomic Clones Encoding Human Myelin Oligodendrocyte Glycoprotein. J Neurochem. 65(1): 309-18.
      • Johns TG, et al. (1999) The Structure and Function of Myelin Oligodendrocyte Glycoprotein. J Neurochem. 72(1): 1-9.

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