MYD88 Antibodies, cDNA Clones Research Reagents

MYD88 (MYD88 Innate Immune Signal Transduction Adaptor, also known as IMD68; MYD88D), located on 3p22.2, is a Protein Coding gene. This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. MYD88 is a key downstream adaptor for most Toll-like receptors (TLRs) and interleukin-1 receptors (IL1Rs), and functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. MYD88 shares 81% amino acid identity with murine MyD88.

MYD88 Antibody (3)

    MYD88 cDNA Clone (18)

    NM_001172566.1

    In expression vector

    NM_010851.2

    In expression vector

    NM_198130.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    MYD88 qPCR Primer (1)

    MYD88 の背景知識

    Myeloid differentiation primary response protein 88 (MyD88) is a critical adaptor protein involved in Toll-like receptor (TLR) and interleukin-1 (IL-1) receptor family signaling controlling innate immune responses and inflammation. MyD88 links IL-1 receptor (IL-1R) or TLR family members to IL-1R-associated kinase (IRAK) family kinases via homotypic protein-protein interaction. Activation of IRAK family kinases leads to a variety of functional outputs, including the activation of nuclear factor-kappa B (NFκB), mitogen-activated protein kinases, and activator protein 1, making MyD88 a central node of inflammatory pathways. Genetic deletion of MyD88 function results in profound suppression of inflammation and reduced resistance of the host to pathogens indicating non-redundant roles of MyD88. Detection of MyD88 expression was to predict the prognosis of various human cancers, e.g., lymphoid, liver, and colorectal cancers.

    MYD88 の参考文献

    • Wang L, et al. (2018) Dual functional roles of the myd88 signaling in colorectal cancer development. Biomed Pharmacother 107 177-184.
    • Gallot YS, et al. (2018) Myd88 is required for satellite cell-mediated myofiber regeneration in dystrophin-deficient mdx mice. Hum Mol Genet 27 (19): 3449-3463.
    • Di Padova F, et al. (2018) Myd88 as a therapeutic target for inflammatory lung diseases. Expert Opin Ther Targets 22 (5): 401-408.
    • Deguine J, et al. (2014) Myd88: A central player in innate immune signaling. F1000Prime Rep 6 97.

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