MYBL2/B-MyB Antibodies, cDNA Clones Research Reagents

MYBL2 (MYB Proto-Oncogene Like 2, also known as BMYB; B-MYB), located on 20q13.12, is a Protein Coding gene. The MYBL2 gene belongs to the MYB family of transcription factor genes and plays an essential role during cell cycle progression. MYBL2 activates CDC2 and cyclin D1 gene expression in proliferating fibroblasts, and antisense oligonucleotides specific to MYBL2 inhibit proliferation of human hematopoietic cell lines. MYBL2 expression is also regulated at the G1/S phase transition, and its transcription relies on E2F activity in a cell cycle-dependent manner.

MYBL2/B-MyB Antibody (1)

    MYBL2/B-MyB cDNA Clone (16)

    BC007585

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_008652.2

    In expression vector

    MYBL2/B-MyB qPCR Primer (1)

    MYBL2/B-MyB の背景知識

    MYBL2 (B-MYB), a member of the MYB family of transcription factor genes, regulates the expression of genes in the process of tumorigenesis. Many studies have shown that MYBL2 is highly expressed in several human malignancies including pancreatic ductal adenocarcinoma (PDAC). Overexpression of MYBL2 might serve as a novel prognostic biomarker in PDAC patients. MYBL2 is a key downstream factor of Akt/FoxM1 signaling to promote the progression of human glioma and could be a new candidate gene for molecular targeting therapy and biomarker for radiotherapy of glioma. MYBL2 (alias B-Myb) is a physiological regulator of cell cycle progression, cell survival, and cell differentiation. When deregulated in cancer cells, MYBL2 mediates the deregulation of these properties. MYBL2 and players of its downstream transcriptional network can be used as prognostic and/or predictive biomarkers as well as potential therapeutic targets to offer less toxic and more specific anti-cancer therapies in the future.

    MYBL2/B-MyB の参考文献

    • Zhang X, et al. (2017) Akt/foxm1 signaling pathway-mediated upregulation of mybl2 promotes progression of human glioma. J Exp Clin Cancer Res 36 (1): 105.
    • Yu R, et al. (2017) Clinicopathologic features and prognostic implications of mybl2 protein expression in pancreatic ductal adenocarcinoma. Pathol Res Pract 213 (8): 964-968.
    • Musa J, et al. (2017) Mybl2 (b-myb): A central regulator of cell proliferation, cell survival and differentiation involved in tumorigenesis. Cell Death Dis 8 (6): e2895.

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