MVD Antibodies, cDNA Clones Research Reagents

MVD (Mevalonate Diphosphate Decarboxylase, also known as MPD; MDDase; POROK7; FP17780), located on 16q24.2, is a Protein Coding gene. The encoded protein belongs to the diphosphomevalonate decarboxylase family. MVD catalyzes the conversion of mevalonate pyrophosphate into isopentenyl pyrophosphate. This unusual enzyme decarboxylates and dehydrates its substrate while hydrolyzing ATP. As a unique enzyme in one of the early steps in cholesterol biosynthesis, MVD may be a useful target for drugs aimed at lowering serum cholesterol levels.

MVD Antibody (1)

    MVD cDNA Clone (45)

    NM_002461.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_138656.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_001260543.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    MVD qPCR Primer (1)

    MVD の背景知識

    MVD (Mevalonate Diphosphate Decarboxylase) is a Protein Coding gene. The MVD gene, located on 16q24.2, is conserved in chimpanzee, Rhesus monkey, dog, and cow, etc. MVD is an important enzyme in the mevalonate pathway catalyzing the ATP-dependent decarboxylation of mevalonate 5-diphosphate (MDP) to yield isopentenyl diphosphate (IPP) which is a ubiquitous precursor for isoprenoids and sterols. The enzyme MVD catalyzes the conversion of mevalonate pyrophosphate into isopentenyl pyrophosphate in one of the early steps in cholesterol biosynthesis. It decarboxylates and dehydrates its substrate while hydrolyzing ATP. Diseases associated with MVD include Porokeratosis 7, Multiple Types, and Porokeratosis. Among its related pathways are Transport to the Golgi and subsequent modification and Sterol Regulatory Element-Binding Proteins (SREBP) signaling.

    MVD の参考文献

    • Weerasinghe S, et al. (2010) Simulation of structural and functional properties of mevalonate diphosphate decarboxylase (mvd). J Mol Model 16 (3): 489-498.
    • Ku EC (1996) Regulation of fatty acid biosynthesis by intermediates of the cholesterol biosynthetic pathway. Biochem Biophys Res Commun 225 (1): 173-179.
    • Dassanayake RS, et al. (2002) Characterization, heterologous expression and functional analysis of mevalonate diphosphate decarboxylase gene (mvd) of candida albicans. Mol Genet Genomics 267 (3): 281-290.

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