MUS81 Antibodies, cDNA Clones Research Reagents

MUS81 (MUS81 Structure-Specific Endonuclease Subunit, also known as SLX3), located on 11q13, is a Protein Coding gene. The encoded protein belongs to the XPF (ERCC4) family of endonucleases and plays a critical role in the resolution of recombination intermediates during DNA repair after inter-strand cross-links, replication fork collapse, and DNA double-strand breaks. MUS81 contains an N-terminal DEAH helicase domain, an excision repair cross complementation group 4 (ERCC4) endonuclease domain, and two tandem C-terminal helix-hairpin-helix domains.

MUS81 Antibody (1)

    MUS81 cDNA Clone (15)

    BC009999

    クローニングベクター cDNA 製品

    In lentiviral vector

    MUS81 qPCR Primer (1)

    MUS81 の背景知識

    Methyl methanesulfonate and UV sensitive gene clone 81 (Mus81) is a critical DNA repair gene that has been implicated in the development of several cancers including hepatocellular carcinoma (HCC). MUS81 may be a potential therapeutic target for epithelial ovarian cancer (EOC). Mus81 is a well-conserved DNA structure-specific endonuclease that belongs to the XPF/Rad1 family of proteins that are involved in DNA nucleotide excision repair. MUS81 is a key endonuclease involved in homologous recombination (HR) repair after DNA double-strand damage. The nucleolytic activity of MUS81 endonuclease is required for replication fork restart under replication stress elicited by exogenous treatments. Mus81 forms a heterodimer with a non-catalytic subunit, Mms4, in Saccharomyces cerevisiae (Eme1/EME1 in Schizosaccharomyces pombe and mammals).

    MUS81 の参考文献

    • Zhong A, et al. (2018) Inhibition of mus81 improves the chemical sensitivity of olaparib by regulating mcm2 in epithelial ovarian cancer. Oncol Rep 39 (4): 1747-1756.
    • Phung HTT, et al. (2018) Saccharomyces cerevisiae mus81-mms4 and rad52 can cooperate in the resolution of recombination intermediates. Yeast 35 (9): 543-553.
    • Palma A, et al. (2018) Phosphorylation by ck2 regulates mus81/eme1 in mitosis and after replication stress. Nucleic Acids Res 46 (10): 5109-5124.
    • Lu R, et al. (2019) Mus81 participates in the progression of serous ovarian cancer associated with dysfunctional DNA repair system. Front Oncol 9 1189.

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