MTSS1 Proteins, Antibodies, cDNA Clones Research Reagents

MTSS1 (MTSS I-BAR Domain Containing 1, also known as MIM; MIMA; MIMB), located on 8q24.13, is a Protein Coding gene. The gene produces an 82251 Da protein composed of 755 amino acids. MTSS1 belongs to a family of proteins containing a conserved N-terminal F-actin-bundling domain, called an IRSP53 (BAIAP2)/MIM homology domain (IMD), involved in filopodia formation. Diseases such as Lung Giant Cell Carcinoma and Wiskott-Aldrich Syndrome are associated with MTSS1. The related pathways of MTSS1 include Hedgehog signaling events mediated by Gli proteins and Cytoskeletal Signaling.

MTSS1 Protein (1)

    MTSS1 Antibody (2)

      MTSS1 cDNA Clone (15)

      NM_014751.4

      クローニングベクター cDNA 製品

      In lentiviral vector

      MTSS1 qPCR Primer (1)

      MTSS1 の背景知識

      MTSS1 (Metastasis suppressor 1), also known as Missing in metastasis (MIM), is a tissue-specific regulator of plasma membrane dynamics. MTSS1 is well described for its function as a metastasis suppressor gene and is expressed in a variety of tissues. MTSS1 might be involved in shaping neuronal membranes in vivo. MTSS1 deforms phosphoinositide-rich membranes through its I-BAR domain and interacts with actin monomers through its WH2 domain. MTSS1/MIM was first identified as a metastasis suppressor missing in metastatic bladder carcinoma cell lines. MTSS1 is a prognostic indicator of disease-free survival in breast cancer patients and demonstrates the ability to play a role in governing the metastatic nature of breast cancer cells. MTSS1 may serve as a useful biomarker for the prediction of the outcome of gastric cancer. The down-regulation of MTSS1 that may be caused by DNA methylation was also observed in many other types of cancer. Recent work proposed that MIM also potentiates Sonic hedgehog (Shh)-induced gene expression. MTSS1 is a multiple functional molecular and has an important role in development, carcinogenesis, and metastasis.

      MTSS1 の参考文献

      • Hayn-Leichsenring G, et al. (2011) Cellular distribution of metastasis suppressor 1 and the shape of cell bodies are temporarily altered in Engrailed-2 overexpressing cerebellar Purkinje cells. Neuroscience. 189: 68-78.
      • Xie F, et al. (2011) MTSS1: a multifunctional protein and its role in cancer invasion and metastasis. Front Biosci (Schol Ed). 3: 621-31.
      • Saarikangas J, et al. (2011) Missing-in-metastasis MIM/MTSS1 promotes actin assembly at intercellular junctions and is required for integrity of kidney epithelia. J Cell Sci. 2124(Pt 8): 1245-55.
      • Parr C, et al. (2009) Metastasis suppressor 1 (MTSS1) demonstrates prognostic value and anti-metastatic properties in breast cancer. Eur J Cancer. 45(9): 1673-83.

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