MTRR Antibodies, cDNA Clones Research Reagents

MTRR (5-Methyltetrahydrofolate-Homocysteine Methyltransferase Reductase, also known as MSR; cblE), located on 5p15.31, is a Protein Coding gene. The MTRR gene encodes methionine synthase reductase. It belongs to a member of the ferredoxin-NADP(+) reductase (FNR) family of electron transferases. MTRR functions in the synthesis of methionine by regenerating methionine synthase to a functional state. The activity of the encoded enzyme is important for folate metabolism and cellular methylation. MTRR may be a potential target for the therapy of ovarian cancer (OC).

MTRR Antibody (1)

    MTRR cDNA Clone (15)

    BC109216

    クローニングベクター cDNA 製品

    In lentiviral vector

    MTRR qPCR Primer (1)

    MTRR の背景知識

    Methionine synthase reductase (MTRR) is one of the important enzymes involved in the folate metabolic pathway and its functional genetic polymorphisms may be associated with breast cancer risk. MTRR A66G polymorphism is not associated with breast cancer risk, especially in Caucasians and Asians. Methionine synthase reductase (MTRR) is involved in the DNA synthesis and production of S-adenosylmethionine (SAM) and plays an important role in carcinogenesis. MTRR expression, which is increased in human ovarian cancer (OC), is related to the differentiation and cisplatin resistance of OC cells. MTRR silencing inhibits cell growth and cisplatin resistance by regulating caspase expression and mTOR signaling pathway in OC cells. It is suggested that MTRR may be a potential target for the therapy of OC.

    MTRR の参考文献

    • Hu J, et al. (2010) Mtrr a66g polymorphism and breast cancer risk: A meta-analysis. Breast Cancer Res Treat 124 (3): 779-784.
    • Chen J, et al. (2015) Mtrr silencing inhibits growth and cisplatin resistance of ovarian carcinoma via inducing apoptosis and reducing autophagy. Am J Transl Res 7 (9): 1510-1527.

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