MTRF1L (Mitochondrial Translational Release Factor 1 Like) is a Protein Coding gene. The MTRF1L gene, located on 6q25.2, is conserved in chimpanzee, Rhesus monkey, and dog, etc. MTRF1L belongs to the prokaryotic/mitochondrial release factor family. The protein encoded by this gene plays a role in mitochondrial translation termination and is thought to be a release factor that is involved in the dissociation of the complete protein from the final tRNA, the ribosome, and the cognate mRNA. This protein acts upon UAA and UAG stop codons but has no in vitro activity against UGA. This protein shares sequence similarity to bacterial release factors. Diseases associated with MTRF1L include Spastic Ataxia 3 and Deafness, Aminoglycoside-Induced. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation.