MTRF1L Antibodies, cDNA Clones Research Reagents

MTRF1L (Mitochondrial Translational Release Factor 1 Like, also known as MRF1L; HMRF1L; mtRF1a), located on 6q25.2, is a Protein Coding gene. The encoded protein plays a role in the termination of mitochondrial translation and is considered a release factor that is involved in the dissociation of the complete protein from the final tRNA, ribosome, and cognate mRNA. MTRF1L belongs to the prokaryotic/mitochondrial release factor family. MTRF1L functions as a releasing factor that recognizes termination codons and releases mitochondrial ribosomes from the synthesized protein.

MTRF1L Antibody (1)

    MTRF1L cDNA Clone (16)

    NM_001114184.2

    In expression vector

    NM_175374.3

    クローニングベクター cDNA 製品

    In lentiviral vector

    MTRF1L qPCR Primer (1)

    MTRF1L の背景知識

    MTRF1L (Mitochondrial Translational Release Factor 1 Like) is a Protein Coding gene. The MTRF1L gene, located on 6q25.2, is conserved in chimpanzee, Rhesus monkey, and dog, etc. MTRF1L belongs to the prokaryotic/mitochondrial release factor family. The protein encoded by this gene plays a role in mitochondrial translation termination and is thought to be a release factor that is involved in the dissociation of the complete protein from the final tRNA, the ribosome, and the cognate mRNA. This protein acts upon UAA and UAG stop codons but has no in vitro activity against UGA. This protein shares sequence similarity to bacterial release factors. Diseases associated with MTRF1L include Spastic Ataxia 3 and Deafness, Aminoglycoside-Induced. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation.

    MTRF1L の参考文献

    • Vieira AR, et al. (2008) Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts. Genet Med 10 (9): 668-674.
    • Nozaki Y, et al. (2008) Hmrf1l is a human mitochondrial translation release factor involved in the decoding of the termination codons uaa and uag. Genes Cells 13 (5): 429-438.
    • Ishizawa T, et al. (2008) The human mitochondrial translation release factor hmrf1l is methylated in the ggq motif by the methyltransferase hmprmc. Biochem Biophys Res Commun 373 (1): 99-103.

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