MTH1 Proteins, Antibodies Research Reagents

NUDT1 (Nudix Hydrolase 1, also known as MTH1), located on 7p22.3, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. The gene produces a 22520 Da protein composed of 197 amino acids. Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. Diseases such as Familial Adenomatous Polyposis and Attenuated Familial Adenomatous Polyposis are associated with NUDT1. The related pathways of NUDT1 include the Metabolism of nucleotides and Metabolism.

MTH1 Protein (1)

    MTH1 Antibody (1)

      MTH1 の背景知識

      NUDT1 (Nudix Hydrolase 1) is a Protein Coding gene. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates to monophosphates, thereby preventing misincorporation. The NUDT1 protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Cancers can survive the oxidative conditions by upregulating nucleoside diphosphate linked moiety X-type motif 1 (NUDT1). MiR-485-5p acts as a tumor suppressor by targeting NUDT1 in gastric cancer (GC). The miR-485-5p/NUDT1 axis is involved in the processes of cell growth and cell motility and plays a key role in the tumorigenesis of GC.

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