MTF1 Antibodies, cDNA Clones Research Reagents

MTF1 (Metal Regulatory Transcription Factor 1, also known as ZRF; MTF-1), located on 1p34.3, is a Protein Coding gene. MTF1 is a six Cys(2)His(2) zinc finger-containing transcription factor required for basal and zinc-induced transcription of metallothionein genes. The protein is a nucleocytoplasmic shuttling protein that accumulates in the nucleus upon heavy metal exposure and binds to promoters containing a metal-responsive element (MRE). MTF1 has an additional function as a transcription factor for the nuclear gene srk1 in fission yeast.

MTF1 Antibody (1)

    MTF1 cDNA Clone (15)

    BC014454

    クローニングベクター cDNA 製品

    In lentiviral vector

    MTF1 qPCR Primer (1)

    MTF1 の背景知識

    Metal-regulatory transcription factor 1 (MTF1) is a conserved metal-binding transcription factor in eukaryotes that binds to conserved DNA sequence motifs, termed metal response elements. MTF1 responds to both metal excess and deprivation, protects cells from oxidative and hypoxic stresses, and is required for embryonic development in vertebrates. Metal response element (MRE) binding transcription factor-1 (MTF1) is a six Cys(2)His(2) zinc finger-containing transcription factor required for basal and zinc-induced transcription of metallothionein genes. Metal-activated transcription factor 1 (MTF1) mediates the induction of metallothioneins I and II by zinc and stress signals. Mtf1 has been characterized as a mitochondrial transcription factor and is shown to regulate mitochondrial transcription. Mtf1 has an additional function as a transcription factor for the nuclear gene srk1 in fission yeast.

    MTF1 の参考文献

    • Tavera-Montañez C, et al. (2019) The classic metal-sensing transcription factor mtf1 promotes myogenesis in response to copper. Faseb j 33 (12): 14556-14574.
    • Sun W, et al. (2012) Targeting mitochondrial transcription in fission yeast with etb, an inhibitor of hsp60, the chaperone that binds to the mitochondrial transcription factor mtf1. Genes Cells 17 (2): 122-131.
    • He X, et al. (2009) Induction of metallothionein i by arsenic via metal-activated transcription factor 1: Critical role of c-terminal cysteine residues in arsenic sensing. J Biol Chem 284 (19): 12609-12621.
    • Guerrerio AL, et al. (2004) Metal ion affinities of the zinc finger domains of the metal responsive element-binding transcription factor-1 (mtf1). Biochemistry 43 (18): 5437-5444.

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