MSRA (Methionine Sulfoxide Reductase A) is a Protein Coding gene. The MSRA gene, located on 8p23.1, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat, etc. MSRA belongs to the MsrA Met sulfoxide reductase family. MsrA is a potent intracellular oxidoreductase and serves as an essential factor that protects cells against oxidative damage. However, the therapeutic use of exogenous MsrA in oxidative stress-induced diseases is limited, because it cannot enter the cells. Considerable evidence indicates a role for MsrA in lens cell resistance to oxidative stress through its maintenance of mitochondrial function. Correspondingly, increased protein methionine sulfoxide (PMSO) is associated with lens aging and human cataract formation, suggesting that loss of MsrA activity is associated with this disease.