MSRA Antibodies, cDNA Clones Research Reagents

MSRA (Methionine Sulfoxide Reductase A, also known as PMSR), located on 8p23.1, is a Protein Coding gene. This gene encodes a potent intracellular oxidoreductase that carries out the reversible oxidation-reduction of methionine sulfoxide to methionine. MSRA belongs to the MsrA Met sulfoxide reductase family. The protein functions to repair oxidative damage to proteins that may occur during oxidative bursts or other situations where reactive oxygen radicals exist. MSRA serves as an essential factor that protects cells against oxidative damage.

MSRA Antibody (1)

    MSRA cDNA Clone (29)

    NM_001135670.2

    In expression vector

    NM_001253712.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    XM_005562601.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    MSRA の背景知識

    MSRA (Methionine Sulfoxide Reductase A) is a Protein Coding gene. The MSRA gene, located on 8p23.1, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat, etc. MSRA belongs to the MsrA Met sulfoxide reductase family. MsrA is a potent intracellular oxidoreductase and serves as an essential factor that protects cells against oxidative damage. However, the therapeutic use of exogenous MsrA in oxidative stress-induced diseases is limited, because it cannot enter the cells. Considerable evidence indicates a role for MsrA in lens cell resistance to oxidative stress through its maintenance of mitochondrial function. Correspondingly, increased protein methionine sulfoxide (PMSO) is associated with lens aging and human cataract formation, suggesting that loss of MsrA activity is associated with this disease.

    MSRA の参考文献

    • Wu Y, et al. (2015) Pep-1-msra ameliorates inflammation and reduces atherosclerosis in apolipoprotein e deficient mice. J Transl Med 13 316.
    • Tarafdar S, et al. (2019) Drosophila methionine sulfoxide reductase a (msra) lacks methionine oxidase activity. Free Radic Biol Med 131 154-161.
    • Fu X, et al. (2017) Methionine sulfoxide reductase a (msra) and its function in ubiquitin-like protein modification in archaea. mBio 8 (5): e01169-17.
    • Brennan LA, et al. (2009) Deletion of mouse msra results in hbo-induced cataract: Msra repairs mitochondrial cytochrome c. Mol Vis 15 985-999.

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