MSK1 Antibodies, cDNA Clones Research Reagents

RPS6KA5 (Ribosomal Protein S6 Kinase A5, also known as MSK1; RLPK; MSPK1), located on 14q32.11, is a Protein Coding gene. The gene produces an 89865 Da protein composed of 802 amino acids. The MSK1 protein contains 2 protein kinase domains, each of which includes the 11 subdomains characteristic of all protein kinases. MSK1 shares 43% protein sequence identity with the MAPKAP-K1 isoforms. RPS6KA5 is widely expressed in the brain, endometrium, and other tissues. Diseases such as Septic Myocarditis and Coffin-Lowry Syndrome are associated with RPS6KA5.

MSK1 Antibody (1)

    MSK1 cDNA Clone (15)

    NM_004755.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    MSK1 qPCR Primer (1)

    MSK1 の背景知識

    RPS6KA5 (Ribosomal Protein S6 Kinase A5, also known as MSK1) is a Protein Coding gene. The RPS6KA5 gene, located on 14q32.11, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, chicken, zebrafish, fruit fly, C.elegans, and frog. RPS6KA5 is a serine/threonine kinase that has been reported to be associated with tumor progression in several types of human cancer. RPS6KA5 is widely expressed in the brain, endometrium, and other tissues. Diseases associated with RPS6KA5 include Septic Myocarditis and Coffin-Lowry Syndrome. Among its related pathways are Adenylate cyclase inhibitory pathway and Nuclear Events (kinase and transcription factor activation). 216 organisms have orthologs with the human gene RPS6KA5.

    MSK1 の参考文献

    • Li J, et al. (2020) Msk1 promotes cell proliferation and metastasis in uveal melanoma by phosphorylating creb. Arch Med Sci 16 (5): 1176-1188.
    • Fu X, et al. (2017) Overexpression of msk1 is associated with tumor aggressiveness and poor prognosis in colorectal cancer. Dig Liver Dis 49 (6): 683-691.
    • Ahn J, et al. (2018) Msk1 functions as a transcriptional coactivator of p53 in the regulation of p21 gene expression. Exp Mol Med 50 (10): 1-12.

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