MSH6 Antibodies, cDNA Clones Research Reagents

MSH6 (MutS Homolog 6, also known as GTBP; HSAP; p160; GTMBP; HNPCC5), located on 2p16.3, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, and frog. The gene produces a 152786 Da protein composed of 1360 amino acids. This gene encodes a member of the DNA mismatch repair MutS family. Germline mutations of MSH6 lead to high susceptibility to glioma, as well as some benign or malignant tumors in other organs.

MSH6 Antibody (5)

    MSH6 cDNA Clone (3)

    NM_000179.2

    In expression vector

    NM_010830.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    MSH6 の背景知識

    MutS homolog 6 (MSH6) is one of the mismatch repair proteins and is encoded by the MSH6 gene, which is located on chromosome 2 and is 23,806 bp in length, including 10 exons and 83 untranslated regions. MutS homolog 6 (MSH6) is the major mismatch contacting component of the MSH2-MSH6 heterodimeric complex (MutSalpha) that mediates DNA mismatch repair (MMR) of simple mispairs and small insertion-deletion loops in eukaryotes. The MSH6 protein consists of 1,358 amino acid residues and forms a heterodimer with another mismatch repair protein, MSH2. The MSH2-MSH6 heterodimeric complex can recognize base-base substitution and single-base insertion/deletion mismatches. Germline mutations of MSH6 lead to high susceptibility to glioma, as well as some benign or malignant tumors in other organs. The MSH6 gene is one of the mismatch repair genes involved in Lynch syndrome and its mutations account for 10-20% of Lynch syndrome.

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