MRPS22 Antibodies, cDNA Clones Research Reagents

MRPS22 (Mitochondrial Ribosomal Protein S22, also known as GIBT; ODG7; GK002; C3orf5; COXPD5; RPMS22), located on 3q23, is a Protein Coding gene. This gene encodes a 28S subunit protein that does not seem to have a counterpart in prokaryotic and fungal-mitochondrial ribosomes. MRPS22 belongs to the mitochondrion-specific ribosomal protein mS22 family. Mouse and human MRPS22 share 78.3% of amino acid identity. Diseases such as Combined Oxidative Phosphorylation Deficiency 5 and Ovarian Dysgenesis 7 are associated with MRPS22.

MRPS22 Antibody (1)

    MRPS22 cDNA Clone (30)

    NM_020191.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_001077530.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    MRPS22 qPCR Primer (1)

    MRPS22 の背景知識

    MRPS22 (Mitochondrial Ribosomal Protein S22) is a Protein Coding gene. The MRPS22 gene, located on 3q23, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, and frog. MRPS22 belongs to the mitochondrion-specific ribosomal protein mS22 family. This gene encodes a 28S subunit protein that does not seem to have a counterpart in prokaryotic and fungal-mitochondrial ribosomes. This gene lies telomeric and is transcribed in the opposite direction from the forkhead box L2 gene. MRPS22 is widely expressed in adrenal, testis, and other tissues. Diseases associated with MRPS22 include Combined Oxidative Phosphorylation Deficiency 5 and Ovarian Dysgenesis 7. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation.

    MRPS22 の参考文献

    • Saada A, et al. (2007) Antenatal mitochondrial disease caused by mitochondrial ribosomal protein (mrps22) mutation. J Med Genet 44 (12): 784-786.
    • Kılıç M, et al. (2017) A patient with mitochondrial disorder due to a novel mutation in mrps22. Metab Brain Dis 32 (5): 1389-1393.
    • Chen A, et al. (2018) Mutations in the mitochondrial ribosomal protein mrps22 lead to primary ovarian insufficiency. Hum Mol Genet 27 (11): 1913-1926.

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