MRPS22 (Mitochondrial Ribosomal Protein S22) is a Protein Coding gene. The MRPS22 gene, located on 3q23, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, and frog. MRPS22 belongs to the mitochondrion-specific ribosomal protein mS22 family. This gene encodes a 28S subunit protein that does not seem to have a counterpart in prokaryotic and fungal-mitochondrial ribosomes. This gene lies telomeric and is transcribed in the opposite direction from the forkhead box L2 gene. MRPS22 is widely expressed in adrenal, testis, and other tissues. Diseases associated with MRPS22 include Combined Oxidative Phosphorylation Deficiency 5 and Ovarian Dysgenesis 7. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial translation.