MRI1 Antibodies, cDNA Clones Research Reagents

MRI1 (Methylthioribose-1-Phosphate Isomerase 1, also known as M1Pi; MRDI; MTNA; Ypr118w), located on 19p13.13, is a Protein Coding gene. This enzyme functions in the methionine salvage pathway by catalyzing the interconversion of methylthioribose-1-phosphate (MTR-1-P) and methythioribulose-1-phosphate (MTRu-1-P). It belongs to the eIF-2B alpha/beta/delta subunits family, MtnA subfamily. MRI1 functions both as an isomerase in the methionine salvage pathway and as a downstream target of RHOA that is required for cell migration.

MRI1 Antibody (1)

    MRI1 cDNA Clone (15)

    BC001703

    クローニングベクター cDNA 製品

    In lentiviral vector

    MRI1 qPCR Primer (1)

    MRI1 の背景知識

    MRI1 (Methylthioribose-1-Phosphate Isomerase 1) is a Protein Coding gene. The MRI1 gene, located on 19p13.13, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, etc. MRI1 belongs to the eIF-2B alpha/beta/delta subunits family, MtnA subfamily. This enzyme functions in the methionine salvage pathway by catalyzing the interconversion of methylthioribose-1-phosphate (MTR-1-P) and methythioribulose-1-phosphate (MTRu-1-P). Elevated expression of the encoded protein is associated with metastatic melanoma and this protein promotes melanoma cell invasion independent of its enzymatic activity. MRI1 is ubiquitously expressed in the placenta, skin, and other tissues. Diseases associated with MRI1 include Spinal Cord Melanoma and Intermittent Squint. Among its related pathways are S-methyl-5-Thio-alpha-D-ribose 1-phosphate degradation and Viral mRNA Translation.

    MRI1 の参考文献

    • Sunker A, et al. (2013) Identification of mri1, encoding translation initiation factor eif-2b subunit alpha/beta/delta-like protein, as a candidate locus for infantile epilepsy with severe cystic degeneration of the brain. Gene 512 (2): 450-452.
    • Li HR, et al. (2020) Overexpression of ei2bl promoted human non-small cell lung cancer progression by inducing cell emt phenotype. J Clin Pathol 73 (3): 139-146.
    • Bumann M, et al. (2004) Crystal structure of yeast ypr118w, a methylthioribose-1-phosphate isomerase related to regulatory eif2b subunits. J Biol Chem 279 (35): 37087-37094.

    Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.