MRI1 (Methylthioribose-1-Phosphate Isomerase 1) is a Protein Coding gene. The MRI1 gene, located on 19p13.13, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, etc. MRI1 belongs to the eIF-2B alpha/beta/delta subunits family, MtnA subfamily. This enzyme functions in the methionine salvage pathway by catalyzing the interconversion of methylthioribose-1-phosphate (MTR-1-P) and methythioribulose-1-phosphate (MTRu-1-P). Elevated expression of the encoded protein is associated with metastatic melanoma and this protein promotes melanoma cell invasion independent of its enzymatic activity. MRI1 is ubiquitously expressed in the placenta, skin, and other tissues. Diseases associated with MRI1 include Spinal Cord Melanoma and Intermittent Squint. Among its related pathways are S-methyl-5-Thio-alpha-D-ribose 1-phosphate degradation and Viral mRNA Translation.