MRAP Proteins, cDNA Clones Research Reagents

MRAP (Melanocortin 2 Receptor Accessory Protein, also known as B27; FALP; FGD2; GCCD2; C21orf61), located on 21q22.11, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat. The gene produces a 19136 Da protein composed of 172 amino acids. This gene encodes a melanocortin receptor-interacting protein. MRAP and MRAP2 are accessory proteins responsible for melanocortin receptor targeting and function. Diseases such as Glucocorticoid Deficiency 2 and Glucocorticoid Deficiency 1 are associated with MRAP. The related pathways of MRAP include Aldosterone synthesis and secretion.

MRAP Protein (1)

    MRAP cDNA Clone (28)

    BC062721

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_001135834.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    MRAP qPCR Primer (2)

    MRAP Lysate (1)

      MRAP の背景知識

      MRAP (Melanocortin 2 Receptor Accessory Protein) is a Protein Coding gene. This gene encodes a melanocortin receptor-interacting protein. It belongs to the MRAP family. MRAP, which contains a single transmembrane domain, has a unique structure, an antiparallel homodimer. MRAP is a single transmembrane domain accessory protein and a critical component of the hypothamo pituitary-adrenal axis. MRAP is highly expressed in the adrenal gland and is essential for adrenocorticotropin hormone (ACTH) receptor expression and function. In adrenal cells, MRAP is essential for adrenocorticotropic hormone (ACTH)-induced activation of the cAMP/protein kinase A (PKA) pathway by melanocortin 2 receptor (MC2R), leading to glucocorticoid production and secretion. Diseases associated with MRAP include Glucocorticoid Deficiency 2 and Glucocorticoid Deficiency 1.

      Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.