MOXD1 Antibodies, cDNA Clones Research Reagents

MOXD1 (Monooxygenase DBH Like 1, also known as MOX; PRO5780; dJ248E1.1), located on 6q23.2, is a Protein Coding gene. The encoded protein belongs to the copper type II ascorbate-dependent monooxygenase family. The deduced 545-amino acid protein has several cysteine residues likely to be involved in disulfide bond formation. It also has a subset of cysteines within the catalytic core that are conserved with DBH and PAM, as well as other conserved residues that are likely to coordinate copper and contribute to enzymatic activity.

MOXD1 Antibody (1)

    MOXD1 cDNA Clone (13)

    NM_015529.3

    クローニングベクター cDNA 製品

    In lentiviral vector

    MOXD1 qPCR Primer (1)

    MOXD1 の背景知識

    By the differential display of genes showing altered expression during senescence in human diploid fibroblasts, Chambers et al. (1998) cloned MOXD1, which they called MOX. DBH-like monooxygenase protein 1, also known as monooxygenase X, is an enzyme that in humans is encoded by the MOXD1 gene. The MOXD1 gene, located on 6q23.2, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, and frog. MOXD1 belongs to the copper type II ascorbate-dependent monooxygenase family. 2 alternatively spliced human isoforms have been reported. MOXD1 is widely expressed in the endometrium, adrenal, and other tissues. DBH-like 1 maintains many of the structural features of dopamine beta-monooxygenase DBH. DBH deficiency has been treated effectively with L-Threo-3,4-dihydroxyphenylserine (DOPS).

    MOXD1 の参考文献

    • Zhang W, et al. (2018) The intracellular nadh level regulates atrophic nonunion pathogenesis through the ctbp2-p300-runx2 transcriptional complex. Int J Biol Sci 14 (14): 2023-2036.
    • Xin X, et al. (2004) Monooxygenase x, a member of the copper-dependent monooxygenase family localized to the endoplasmic reticulum. J Biol Chem 279 (46): 48159-48167.
    • Chambers KJ, et al. (1998) Identification and cloning of a sequence homologue of dopamine beta-hydroxylase. Gene 218 (1-2): 111-120.

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