MORC1 Antibodies, cDNA Clones Research Reagents

MORC1 (MORC Family CW-Type Zinc Finger 1, also known as CT33; MORC; ZCW6), located on 3q13.13, is a Protein Coding gene. This gene encodes the human homolog of mouse Morc and like the mouse protein, it is testis-specific. Human MORC encodes a deduced 984-amino acid protein with 66% overall identity to mouse Morc. It is required for spermatogenesis. Sequence analysis detected a bipartite nuclear localization signal, 2 coiled-coil domains, and a leucine zipper motif. Accumulating biochemical and functional analyses unveil MORC proteins as key regulators for cancer development.

MORC1 Antibody (1)

    MORC1 cDNA Clone (15)

    BC050307

    クローニングベクター cDNA 製品

    In lentiviral vector

    MORC1 qPCR Primer (1)

    MORC1 の背景知識

    MORC1 was first discovered as a key regulator for male meiosis and spermatogenesis. Accumulating biochemical and functional analyses unveil MORC proteins as key regulators for cancer development. The MORC family contains a combination of a gyrase, histidine kinase, and MutL (GHKL) and S5 domains that together constitute a catalytically active ATPase module. The MORC1 gene is a link between early-life stress and major depression. MORC1 is a stress-sensitive gene and a possible biomarker for depression. MORC1-deficient mice were previously found to display male-specific germ cell loss and infertility. MORC1 is an important new regulator of the epigenetic landscape of male germ cells during the period of global de novo methylation.

    MORC1 の参考文献

    • Pastor WA, et al. (2015) Erratum: Morc1 represses transposable elements in the mouse male germline. Nat Commun 6 7604.
    • Mundorf A, et al. (2018) Methylation of morc1: A possible biomarker for depression? J Psychiatr Res 103 208-211.
    • Iyer LM, et al. (2008) Mutl homologs in restriction-modification systems and the origin of eukaryotic morc atpases. Biol Direct 3 8.
    • Hong G, et al. (2017) The emerging role of morc family proteins in cancer development and bone homeostasis. J Cell Physiol 232 (5): 928-934.

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