MNS1 Antibodies, cDNA Clones Research Reagents

MNS1 (Meiosis Specific Nuclear Structural 1, also known as HTX9; SPATA40), located on 15q21.3, is a Protein Coding gene. The MNS1 gene encodes a meiosis-specific structural protein expressed at the pachytene stage during spermatogenesis, thought to have a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis. It belongs to the MNS1 family. MNS1 also plays an essential role in motile ciliary function and sperm flagella assembly. The protein has three potential N-glycosylation sites and a calcium-binding consensus sequence.

MNS1 Antibody (1)

    MNS1 cDNA Clone (15)


    クローニングベクター cDNA 製品

    In lentiviral vector

    MNS1 qPCR Primer (1)

    MNS1 の背景知識

    The gene, designated MNS1, encodes a 549-amino acid polypeptide of calculated molecular size 63,017 Da produced by an mRNA species of approximately 1.7 kilobases. The protein possesses a putative non-cleavable signal sequence near its N-terminal region which probably acts as a transmembrane domain. It has three potential N-glycosylation sites and a calcium-binding consensus sequence. MNS1 (meiosis-specific nuclear structural protein 1) is necessary for motile cilia function, such as sperm flagella or those found in the embryonic primitive node. MNS1 is expressed in the germ cells in the testes and localizes to sperm flagella in a detergent-resistant manner, indicating that it is an integral component of flagella. MNS1-deficient males are sterile, as they exhibit a sharp reduction in sperm production and the remnant sperm are immotile with abnormal short tails. MNS1 is essential for spermiogenesis, the assembly of sperm flagella, and motile ciliary functions.

    MNS1 の参考文献

    • Zhou J, et al. (2012) Mns1 is essential for spermiogenesis and motile ciliary functions in mice. PLoS Genet 8 (3): e1002516.
    • Vadnais ML, et al. (2014) Mitochondrial fusion protein mfn2 interacts with the mitostatin-related protein mns1 required for mouse sperm flagellar structure and function. Cilia 3 5.
    • Camirand A, et al. (1991) Glycoprotein biosynthesis in saccharomyces cerevisiae. Isolation and characterization of the gene encoding a specific processing alpha-mannosidase. J Biol Chem 266 (23): 15120-15127.
    • Boschen KE, et al. (2018) Knockdown of mns1 increases susceptibility to craniofacial defects following gastrulation-stage alcohol exposure in mice. Alcohol Clin Exp Res 42 (11): 2136-2143.

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