MNAT1 Antibodies, cDNA Clones Research Reagents

MNAT1 (MNAT1 Component Of CDK Activating Kinase, also known as MAT1; TFB3; CAP35; RNF66), located on 14q23.1, is a Protein Coding gene. The encoded protein, along with cyclin H and CDK7, forms the CDK-activating kinase (CAK) enzymatic complex. MNAT1 is highly expressed in various cancers and is involved in cancer pathogenesis. Abnormal up-regulation of MNAT1 has been associated with the poor prognosis of multiple cancers. Bioinformatics analysis showed that has-circ-0001146 and miR-26a-5p were involved in the regulation of MNAT1 in osteosarcoma.

MNAT1 Antibody (1)

    MNAT1 cDNA Clone (32)

    NM_002431.2

    In expression vector

    In lentiviral vector

    NM_008612.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_153472.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    MNAT1 の背景知識

    MNAT1 (menage a trois 1, MAT1), a cyclin-dependent kinase-activating kinase (CAK) complex, high expresses in various cancers and is involved in cancer pathogenesis. MNAT1 is a subunit in the cyclin-dependent kinase-activating kinase complex. Abnormal up-regulation of MNAT1 has been associated with the poor prognosis of multiple cancers. Bioinformatics analysis showed that has-circ-0001146 and miR-26a-5p were involved in the regulation of MNAT1 in osteosarcoma. has-circ-0001146 blocked miR-26a-5p targeting MNAT1 in osteosarcoma cells, thereby promoting the malignant behaviors of osteosarcoma cells. MNAT1 binds to p53, mediates p53 ubiquitin-degradation through MDM2, increases cell growth and decreases cell apoptosis, and finally promotes CRC malignancy. MNAT1 binding to p53 and mediating p53 ubiquitin-degradation axis represents a novel molecular joint in the p53 pathway.

    MNAT1 の参考文献

    • Zhou S, et al. (2018) Mnat1 is overexpressed in colorectal cancer and mediates p53 ubiquitin-degradation to promote colorectal cancer malignance. J Exp Clin Cancer Res 37 (1): 284.
    • Wang J, et al. (2020) The regulatory effect of has-circ-0001146/mir-26a-5p/mnat1 network on the proliferation and invasion of osteosarcoma. Biosci Rep 40 (6): BSR20201232.

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