MMP13 Antibodies, cDNA Clones Research Reagents

MMP13 (Matrix Metallopeptidase 13, also known as CLG3; MDST; MANDP1; MMP-13), located on 11q22.2, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, C.elegans, and frog. The gene produces a 53820 Da protein composed of 471 amino acids. This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Diseases such as Spondyloepimetaphyseal Dysplasia, Missouri Type, and Metaphyseal Dysplasia, Spahr Type are associated with MMP13. The related pathways of MMP13 include G-protein signaling Ras family GTPases in kinase cascades (scheme) and Cell adhesion_Plasmin signaling.

MMP13 Antibody (3)

    MMP13 cDNA Clone (29)

    NM_002427

    クローニングベクター cDNA 製品

    In lentiviral vector

    BC067522

    In lentiviral vector

    NM_008607.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_133530.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    MMP13 qPCR Primer (1)

    MMP13 の背景知識

    Matrix metalloproteinases (MMPs) such as MMP13 promote tumor growth and progression by mediating extracellular matrix (ECM) reorganization and regulating the biological activity of cytokines. Matrix metalloproteinase 13 (MMP13) plays a central role in the MMP activation cascade that enables degradation of the extracellular matrix and basement membranes, and it is identified as a potential driver in oral carcinogenesis.MMP13 is enriched in mature chondrocytes and is considered a prime cause of ECM degradation in the osteoarthritic articular cartilage in temporomandibular joints. A missense mutation of MMP13 causes the Missouri type of human Spondyloepimetaphyseal dysplasia (SEMD(MO)), an autosomal dominant disorder characterized by defective growth and modeling of vertebrae and long bones.

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