MMP12 Proteins, Antibodies, cDNA Clones Research Reagents

MMP12 (Matrix Metallopeptidase 12, also known as ME; HME; MME; MMP-12), located on 11q22.2, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat. The gene produces a 54002 Da protein composed of 470 amino acids. This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Diseases such as Pulmonary Emphysema and Dermatitis Herpetiformis are associated with MMP12. The related pathways of MMP12 include the Degradation of the extracellular matrix and TGF-beta Signaling Pathway (WikiPathways).

MMP12 Protein (1)

    MMP12 Antibody (1)

      MMP12 cDNA Clone (25)

      NM_002426.4

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_008605.3

      MMP12 qPCR Primer (1)

      MMP12 の背景知識

      Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, differentiation, angiogenesis, and tissue remodeling, as well as pathological processes including inflammation, arthritis, cardiovascular diseases, pulmonary diseases, and tumor invasion. Macrophage Metalloelastase, also known as Matrix metalloproteinase-12, Macrophage elastase, MMP12, and MMP-12, is a secreted protein that belongs to the peptidase M1A family. MMP12 is a macrophage-secreted elastase that is highly induced in the liver and lung in response to S. mansoni eggs and contains four hemopexin-like domains. MMP12 is a proteolytic enzyme responsible for the cleavage of plasminogen to angiotensin, which has an angiostatic effect. It may be involved in tissue injury and remodeling and has significant elastolytic activity. It may be related to prognosis in breast cancer patients. MMP12 promotes fibrosis by limiting the expression of specific ECM-degrading MMPs. Like MMP12, MMP13 expression is highly dependent on IL-13 and type I I-IL-4 receptor signaling. MMP12 is a potent proinflammatory and oncogenic molecule. MMP12 up-regulation plays a critical role in emphysema to lung cancer transition that is facilitated by inflammation.

      MMP12 の参考文献

      • Shapiro S.D., et al.,(1993), Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages. J. Biol. Chem. 268:23824-23829.
      • Gronski T.J. Jr., et al., (1997), Hydrolysis of a broad spectrum of extracellular matrix proteins by human macrophage elastase.J. Biol. Chem. 272:12189-12194.
      • Ota T., et al.,(2004), Complete sequencing and characterization of 21,243 full-length human cDNAs.Nat. Genet. 36:40-45.

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