MMP1 Proteins, Antibodies, cDNA Clones Research Reagents

MMP1 (Matrix Metallopeptidase 1, also known as CLG; CLGN), located on 11q22.2, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and chicken. The gene produces a 54007 Da protein composed of 469 amino acids. This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Diseases such as Epidermolysis Bullosa Dystrophica, Autosomal Recessive, and Recessive Dystrophic Epidermolysis Bullosa are associated with MMP1. The related pathways of MMP1 include G-protein signaling Ras family GTPases in kinase cascades (scheme) and Degradation of the extracellular matrix.

MMP1 Protein (1)

    MMP1 Antibody (1)

      MMP1 cDNA Clone (13)

      NM_002421.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      MMP1 qPCR Primer (1)

      MMP1 Lysate (1)

        MMP1 の背景知識

        MMP1, also known as MMP-1, contains 4 hemopexin-like domains and is a member of the matrix metalloproteinase (MMP) family. Matrix metalloproteases, also called matrixins, are zinc-dependent endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a wide range of extracellular molecules and some bioactive molecules. MMP activity is regulated by two major endogenous inhibitors: alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell proliferation, migration, differentiation, angiogenesis, apoptosis, and host defenses. Dysregulation of MMPs has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis, and cancer. Tumour metastasis is a multistep process involving the dissemination of tumor cells from the primary tumor to secondary at a distant organ or tissue. One of the first steps in metastasis is the degradation of the basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all have elevated expression in primary tumors and/or metastases. MMP-1 cleaves collagens of types I, II, and III at one site in the helical domain. It also cleaves collagens of types VII and X. In case of HIV infection, MMP1 interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.

        MMP1 の参考文献

        • Gross J, et al. (1962) Collagenolytic Activity in Amphibian Tissues: A Tissue Culture Assay. Proceedings of the National Academy of Sciences. 48(6):1014-22.
        • Pendas, et al. (1996) Fine Physical Mapping of the Human Matrix Metalloproteinase Genes Clustered on Chromosome 11q22.3. Genomics. 37(2):266-8.
        • Brinckerhoff C E, et al. (1987) Molecular cloning of human synovial cell collagenase and selection of a single gene from genomic DNA. Journal of Clinical Investigation. 79(2):542-6.

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