MKNK1 Antibodies, cDNA Clones Research Reagents

MKNK1 (MAPK Interacting Serine/Threonine Kinase 1, also known as MNK1), located on 1p33, is a Protein Coding gene. MKNK1 encodes a predicted 424-amino acid protein containing a sequence typical of the catalytic domain of serine/threonine kinases and a putative N-terminal nuclear localization signal sequence. MKNK1 belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family. The Ser/Thr protein kinase MKNK1 interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines.

MKNK1 Antibody (1)

    MKNK1 cDNA Clone (30)

    NM_198973.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_001285487.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    MKNK1 qPCR Primer (1)

    MKNK1 の背景知識

    The MAPK-interacting kinase 1 (MKNK1) is localized downstream of the RAS/RAF/ERK and the MAP3K1/MKK/p38 signaling pathway. Through phosphorylation, MKNK1 regulates the function of eukaryotic translation initiation factor 4E, a key player in translational control, whose expression is often upregulated in metastatic colorectal cancer patients (mCRC). Preclinical data suggest that MKNK1 increases angiogenesis by upregulating angiogenic factors. MKNK1 polymorphism rs8602 might serve as a predictive marker in KRAS wild-type mCRC patients treated with FOLFIRI/Bev in the first-line setting. Additionally, MKNK1 might be a promising target for drug development. Expression of MKNK1 is associated with increased glioma grade and correlated with the mesenchymal GSC marker, CD44, and coexpression of MKNK1 and CD44 predicts poor survival in glioblastoma multiforme.

    MKNK1 の参考文献

    • Berger MD, et al. (2017) Impact of genetic variations in the mapk signaling pathway on outcome in metastatic colorectal cancer patients treated with first-line folfiri and bevacizumab: Data from fire-3 and tribe trials. Ann Oncol 28 (11): 2780-2785.
    • Bell JB, et al. (2016) Mnk inhibition disrupts mesenchymal glioma stem cells and prolongs survival in a mouse model of glioblastoma. Mol Cancer Res 14 (10): 984-993.

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