MIS12 (MIS12 Kinetochore Complex Component) is a Protein Coding gene. The MIS12 gene, located on 17p13.2, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. Mis12 is evolutionarily conserved from yeast to human. MIS12 is part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. The Mis12 complex forms the central scaffold of the kinetochore and serves to bridge the chromatin and microtubule-binding activities of the inner and outer layers, respectively. MIS12 is widely expressed in the thyroid, lymph node, and other tissues. Diseases associated with MIS12 include Tick-Borne Relapsing Fever and Microcephaly 4, Primary, Autosomal Recessive.