MIS12 Antibodies, cDNA Clones Research Reagents

MIS12 (MIS12 Kinetochore Complex Component, also known as MTW1; hMis12; KNTC2AP; 2510025F08Rik), located on 17p13.2, is a Protein Coding gene. The encoded protein is a part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. The MIS12 complex forms the central scaffold of the kinetochore. MIS12 belongs to the mis12 family and is essential for proper kinetochore-microtubule attachments. It has been shown to interact with NSL1, ZWINT, CASC5, Polyamine-modulated factor 1, NDC80, DSN1, and CBX5.

MIS12 Antibody (1)

    MIS12 cDNA Clone (30)

    NM_001258218.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_025993.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    MIS12 の背景知識

    MIS12 (MIS12 Kinetochore Complex Component) is a Protein Coding gene. The MIS12 gene, located on 17p13.2, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. Mis12 is evolutionarily conserved from yeast to human. MIS12 is part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. The Mis12 complex forms the central scaffold of the kinetochore and serves to bridge the chromatin and microtubule-binding activities of the inner and outer layers, respectively. MIS12 is widely expressed in the thyroid, lymph node, and other tissues. Diseases associated with MIS12 include Tick-Borne Relapsing Fever and Microcephaly 4, Primary, Autosomal Recessive.

    MIS12 の参考文献

    • Singleton MR (2016) Getting to the heart of an unusual kinetochore. Open Biol 6 (4): 160040.
    • Rago F, et al. (2015) Distinct organization and regulation of the outer kinetochore kmn network downstream of cenp-c and cenp-t. Curr Biol 25 (5): 671-677.
    • Goshima G, et al. (2003) The role of ppe1/pp6 phosphatase for equal chromosome segregation in fission yeast kinetochore. Embo j 22 (11): 2752-2763.

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