mGluR5/GRM5 Antibodies, cDNA Clones Research Reagents

Metabotropic glutamate receptor 5 (mGluR5/GRM5) is a Gαq/11-coupled receptor, mainly found at the postsynaptic site. mGluR5 stimulation leads to the activation of phospholipase Cβ1 (PLCβ), promoting diacylglicerol (DAG) and inositol 1,4,5-trisphosphate (IP3) formation, which leads to the release of Ca2+ from the intracellular stores and the activation of protein kinases, including protein kinase C. Additionally, stimulation of mGluR5 also triggers the activation of other cell signaling pathways that are important for cell proliferation and survival, such as the activation of the extracellular signal regulated protein kinase (ERK) and AKT. mGluR5 has also been implicated in the pathology of other neurodegenerative diseases, including Alzheimer and Parkinson’s disease, as well as in physiological processes, including memory and motor coordination.