mGluR5/GRM5 Antibodies, cDNA Clones Research Reagents

GRM5 (Glutamate Metabotropic Receptor 5) is a protein coding gene located on human chromosome 11q14.2-q14.3. GRM5 is also known as mGlu5, GPRC1E, MGLUR5 and PPP1R86. The human GRM5 gene encodes a 132469 Da protein containing 1212 amino acids. The GRM5 protein is restrictedly expressed toward brain. Among its related pathways are Neuroscience and GABAergic synapse. GRM5 is related to G protein-coupled receptor activity and A2A adenosine receptor binding. GRM1 is an important paralog of GRM5 gene. GRM5 is associated with some diseases, including Fragile X Syndrome and Fragile X-Associated Tremor/Ataxia Syndrome.

mGluR5/GRM5 Antibody (1)

    mGluR5/GRM5 cDNA Clone (2)

    NM_000842.4

    In expression vector

    NM_001143831.2

    In expression vector

    mGluR5/GRM5 の背景知識

    Metabotropic glutamate receptor 5 (mGluR5/GRM5) is a Gαq/11-coupled receptor, mainly found at the postsynaptic site. mGluR5 stimulation leads to the activation of phospholipase Cβ1 (PLCβ), promoting diacylglicerol (DAG) and inositol 1,4,5-trisphosphate (IP3) formation, which leads to the release of Ca2+ from the intracellular stores and the activation of protein kinases, including protein kinase C. Additionally, stimulation of mGluR5 also triggers the activation of other cell signaling pathways that are important for cell proliferation and survival, such as the activation of the extracellular signal regulated protein kinase (ERK) and AKT. mGluR5 has also been implicated in the pathology of other neurodegenerative diseases, including Alzheimer and Parkinson’s disease, as well as in physiological processes, including memory and motor coordination.

    mGluR5/GRM5 の参考文献

    • Kelly E, et al. (2018) Mglur5 modulation of behavioral and epileptic phenotypes in a mouse model of tuberous sclerosis complex. Neuropsychopharmacology 43 (6): 1457-1465.
    • Carvalho TG, et al. (2017) Mglur5, cb1 and neuroprotection. Oncotarget 8 (3): 3768-3769.
    • Aloisi E, et al. (2017) Altered surface mglur5 dynamics provoke synaptic nmdar dysfunction and cognitive defects in fmr1 knockout mice. Nat Commun 8 (1): 1103.

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