MFI2 Proteins, Antibodies, cDNA Clones Research Reagents

MELTF (Melanotransferrin, also known as MTf; MFI2; MTF1; CD228; MAP97), located on 3q29, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, and frog. The gene produces an 80215 Da protein composed of 738 amino acids. The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. Diseases such as Osteogenic Sarcoma and Melanotic Neuroectodermal Tumor are associated with MELTF. The related pathways of MELTF include the Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins.

MFI2 Protein (2)

    MFI2 Antibody (3)

      MFI2 cDNA Clone (27)


      In expression vector


      クローニングベクター cDNA 製品

      In lentiviral vector


      クローニングベクター cDNA 製品

      In lentiviral vector

      MFI2 qPCR Primer (2)

      MFI2 Lysate (2)

        MFI2 の背景知識

        MELTF (Melanotransferrin, also known as MFI2) is a Protein Coding gene. The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. MELTF is broadly expressed in the salivary gland, kidney, and other tissues. The long non-coding RNA MFI2 antisense RNA is overexpressed in human cancer tissues and its increased expression is associated with the occurrence and metastasis of cancer. lncRNA MFI2 could promote proliferation and migration of osteosarcoma cells by regulating FOXP4 expression, which suggested critical roles of lncRNA MFI2 and FOXP4 in the occurrence and development of human osteosarcoma. Diseases associated with MELTF include Osteogenic Sarcoma and Melanotic Neuroectodermal Tumor.

        MFI2 の参考文献

        • Richardson DR. (2000) The role of the membrane-bound tumour antigen, melanotransferrin (p97), in iron uptake by the human malignant melanoma cell. Eur J Biochem. 267(5): 1290-8.
        • Kim DK, et al. (2001) Serum melanotransferrin, p97 as a biochemical marker of Alzheimer's disease. Neuropsychopharmacology. 25(1): 84-90.
        • Rothenberger S, et al. (1996) Coincident expression and distribution of melanotransferrin and transferrin receptor in human brain capillary endothelium. Brain Res. 712(1): 117-21.
        • Baker EN, et al. (1992) Human melanotransferrin (p97) has only one functional iron-binding site. FEBS Lett. 298(2-3): 215-8.

        Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.