MFGE8 Proteins, cDNA Clones Research Reagents

MFGE8 (Milk Fat Globule EGF And Factor V/VIII Domain Containing, also known as BA46; HMFG; MFGM; SED1; EDIL1; MFG-E8; SPAG10; OAcGD3S; HsT19888), located on 15q26.1, is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, and frog. The gene produces a 43105 Da protein composed of 387 amino acids. This gene encodes a preproprotein that is proteolytically processed to form multiple protein products. Diseases such as Anal Paget's Disease and Opisthorchiasis are associated with MFGE8. The related pathways of MFGE8 include the Metabolism of proteins and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3.

MFGE8 Protein (2)

    MFGE8 cDNA Clone (26)

    NM_005928.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_012811.3

    クローニングベクター cDNA 製品

    In lentiviral vector

    MFGE8 qPCR Primer (2)

    MFGE8 Lysate (1)

      MFGE8 の背景知識

      MFG-E8, also known as lactadherin and MFGE8, contains 1 EGF-like domain and 2 F5/8 type C domains. It also contains phosphatidylserine (PS) binding domain, as well as an Arginine-Glycine-Aspartic acid motif, which enables the binding to integrins. It binds PS, which is exposed on the surface of apoptotic cells. MFG-E8 is expressed in mammary epithelial cell surfaces and aortic media. Overexpression of MFG-E8 can be found in several carcinomas. MFG-E8 has opsonization of the apoptotic cells and binding to integrins on the surface of phagocytic cells. It also mediates the engulfment of the dead cell. MFG-E8 plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. It promotes VEGF-dependent neovascularization and contributes to the phagocytic removal of apoptotic cells in many tissues. It also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner.

      MFGE8 の参考文献

      • Oshima K, et al. (2002) Secretion of a peripheral membrane protein, MFG-E8, as a complex with membrane vesicles. Eur J Biochem. 269(4):1209-18.
      • Hanayama R, et al. (2002) Identification of a factor that links apoptotic cells to phagocytes. Nature. 417 (6885):182-7.
      • Strausberg RL, et al. (2003) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci. 99(26):16899-903.

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