MFAP4 Antibodies, cDNA Clones Research Reagents

MFAP4 (Microfibril Associated Protein 4), located on 17p11.2, is a Protein Coding gene. This gene encodes a protein with similarity to a bovine microfibril-associated protein. The N-terminus of the protein contains an RGD sequence that serves as the ligand motif for cell surface receptor integrin. MFAP4 is an extracellular protein belonging to the fibrinogen-related protein superfamily and plays a potential role in the extracellular matrix (ECM) turnover. It is involved in cell adhesion or intercellular interactions. MFAP4 plays multifaceted roles in innate immunity and normal endothelial function.

MFAP4 Antibody (1)

    MFAP4 cDNA Clone (41)

    NM_002404.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_029568.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_001034124.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    XM_006246476.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    MFAP4 qPCR Primer (1)

    MFAP4 の背景知識

    Microfibrillar-associated protein 4 (MFAP4) is an integrin ligand localized to extracellular matrix fibers in the vascular wall. Microfibrillar-associated protein 4 (MFAP4) is an extracellular protein belonging to the fibrinogen-related protein superfamily and plays a potential role in extracellular matrix (ECM) turnover and was recently identified as a biomarker for hepatic fibrosis in hepatitis C patients. Microfibrillar-associated protein 4 (MFAP4) is a non-structural matrix protein with cell regulatory activities and a potential seromarker for fibrosis. MFAP4 regulates integrin αVβ3-induced VSMC proliferation and migration, as well as monocyte chemotaxis, and accelerates neointimal hyperplasia after vascular injury. MFAP4 plays multifaceted roles in innate immunity and normal endothelial function. It has been proposed that MFAP4 promotes the development of asthma in vivo and proasthmatic pathways of bronchial smooth muscle cells in vitro.

    MFAP4 の参考文献

    • Schlosser A, et al. (2016) Mfap4 promotes vascular smooth muscle migration, proliferation and accelerates neointima formation. Arterioscler Thromb Vasc Biol 36 (1): 122-133.
    • Mölleken C, et al. (2016) Mfap4: A candidate biomarker for hepatic and pulmonary fibrosis? Sarcoidosis Vasc Diffuse Lung Dis 33 (1): 41-50.
    • Milićević NM, et al. (2016) The role of microfibrillar-associated protein 4 (mfap4) in the formation and function of splenic compartments during embryonic and adult life. Cell Tissue Res 365 (1): 135-145.
    • Hoffmann-Petersen B, et al. (2019) Microfibrillar-associated protein 4 in serum is associated with asthma in danish adolescents and young adults. Immun Inflamm Dis 7 (3): 150-159.

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