METTL7B Antibodies, cDNA Clones Research Reagents

METTL7B (Methyltransferase Like 7B, also known as ALDI), located on 12q13.2, is a Protein Coding gene. METTL7B encodes a protein that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (SAM) to hydrogen sulfide (H2S) to form methanethiol (CH3SH). It belongs to the methyltransferase superfamily. METTL7B is implicated in tumor growth and progression while gene expression is upregulated in several different disease states such as rheumatoid arthritis and breast cancer. METTL7B is a potential molecular target for the treatment of non-small cell lung cancer (NSCLC).

METTL7B Antibody (1)

    METTL7B cDNA Clone (26)

    NM_152637.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_027853.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    METTL7B qPCR Primer (1)

    METTL7B の背景知識

    One member of the mammalian methyltransferase-like family (METTL), METTL7B, is a potential molecular target for the treatment of non-small cell lung cancer (NSCLC). METTL7B expression was elevated in the majority of NSCLC comparing to normal tissues. Increased expression of METTL7B contributed to advanced stages of tumor development and poor survival in NSCLC patients. Abundant cell cycle-related genes were downregulated in the absence of METTL7B. Pathway enrichment analysis indicated that METTL7B participated in cell cycle regulation. Notably, CCND1, a key regulator for G1/S transition, was significantly decreased with the depletion of METTL7B, resulting in G0/G1 arrest, indicating that METTL7B is critical for cell cycle progression. METTL7B may promote metastasis of thyroid cancer through EMT and may therefore be considered as a potential biomarker for the diagnosis and prognosis of thyroid carcinoma.

    METTL7B の参考文献

    • Ye D, et al. (2019) Mettl7b promotes migration and invasion in thyroid cancer through epithelial-mesenchymal transition. J Mol Endocrinol 63 (1): 51-61.
    • Liu D, et al. (2020) Mettl7b is required for cancer cell proliferation and tumorigenesis in non-small cell lung cancer. Front Pharmacol 11 178.

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