METTL11A Proteins, Antibodies, cDNA Clones Research Reagents

NTMT1 (N-Terminal Xaa-Pro-Lys N-Methyltransferase 1, also known as NRMT; NRMT1; NTM1A; AD-003; HOMT1A; C9orf32; METTL11A), located on 9q34.11, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog. The gene produces a 25387 Da protein composed of 223 amino acids. The METTL11A gene encodes an N-terminal methyltransferase for the Ran guanine nucleotide exchange factor regulator of chromosome condensation 1 (RCC1). Diseases such as Retinitis Pigmentosa 42 are associated with NTMT1. The related pathways of NTMT1 include DNA Damage.

METTL11A Protein (2)

    METTL11A Antibody (2)

      METTL11A cDNA Clone (29)

      NM_014064.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      METTL11A qPCR Primer (1)

      METTL11A の背景知識

      Methyltransferase-like protein 11A, also known as METTL11A, is a member of the methyltransferase superfamily and METTL11 family. Methyltransferase is a type of transferase enzyme which transfers a methyl group from a donor to an acceptor. Methylation often occurs on nucleic bases in DNA or amino acids in protein structures. Methyltransferase uses a reactive methyl group bound to sulfur in S-adenosyl methionine (SAM) as the methyl donor. DNA methylation is often utilized to silence and regulate genes without changing the original DNA sequence. This methylation occurs on cytosine residues. DNA methylation may be necessary for normal growth from embryonic stages in mammals. Methylation can serve to protect DNA from enzymatic cleavage since restriction enzymes are unable to bind and recognize externally modified sequences. This is especially useful in bacterial restriction-modification systems which use restriction enzymes to cleave foreign DNA while keeping their DNA protected by methylation. Methylation of amino acids in the formation of proteins leads to more diversity of possible amino acids and therefore more diversity of function. The methylation reaction occurs on nitrogen atoms either on the N terminus or side-chain position of the protein and is usually irreversible.

      METTL11A の参考文献

      • Hu R.-M., et al.,(2000), Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548.
      • Ota T., et al., (2004), Complete sequencing and characterization of 21,243 full-length human cDNAs.Nat. Genet. 36:40-45.
      • Humphray S.J., et al.,(2004), DNA sequence and analysis of human chromosome 9.Nature 429:369-374.

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