METTL1 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

METTL1 (Methyltransferase Like 1, also known as TRM8; TRMT8; C12orf1; YDL201w), located on 12q14.1, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog. The gene produces a 31471 Da protein composed of 276 amino acids. This gene is similar in sequence to the S. Diseases such as Thiamine-Responsive Megaloblastic Anemia Syndrome and Isolated Growth Hormone Deficiency, Type Ia are associated with METTL1. The related pathways of METTL1 include Gene Expression and MAPK Erk Pathway.

METTL1 Protein (1)

    METTL1 Antibody (4)

      METTL1 ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(1)

      METTL1 cDNA Clone (30)

      NM_005371.5

      クローニングベクター cDNA 製品

      In lentiviral vector

      XM_001054797.5

      クローニングベクター cDNA 製品

      In lentiviral vector

      METTL1 qPCR Primer (2)

      METTL1 の背景知識

      tRNA (guanine-N(7)-)-methyltransferase, also known as Methyltransferase-like protein 1, tRNA (m7G46)-methyltransferase and METTL1, is a nucleus protein that belongs to the methyltransferase superfamily and TrmB family. METTL1 gene has been identified by its sequence similarity to the yeast ORF YDL21w. The human cDNA and the genomic structure of METTL1 have been analyzed. The transcript contains 1292 nucleotides and codes for a protein of 276 amino acids. The METTL1 gene product shows high sequence similarities to putative proteins from mouse, Drosophila melanogaster, Arabidopsis thaliana, Caenorhabditis elegans, and yeast (39.8% identity between all six species). Computer analyses of the deduced protein sequence reveal two highly conserved amino acid motifs, one of which is typical for methyltransferases. Both motifs are also present in hypothetical proteins from eubacteria. Disruption of the homologous yeast ORF YDL21w shows that the gene is at least not essential for vegetative growth in Saccharomyces cerevisiae.

      METTL1 の参考文献

      • Bahr, A.et al., 1999, Genomics. 57 (3):424-8.
      • Wikman, H. et al., 2005,Genes Chromosomes Cancer. 42 (2):193-9.
      • Cartlidge, RA. et al., 2005, EMBO J. 24 (9):1696-705.

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