MED8 Antibodies, cDNA Clones Research Reagents

MED8 (Mediator Complex Subunit 8, also known as ARC32), located on 1p34.2, is a Protein Coding gene. MED8 is a component of the mediator complex, which in S. cerevisiae is composed of more than 20 subunits and aids in transcriptional activation through interaction with RNA polymerase II and gene-specific transcription factors. It belongs to the Mediator complex subunit 8 family. The encoded protein may also function in ubiquitin ligation and protein degradation. MED8 has proved to possess crucial functions in many organisms from yeast to human.

MED8 Antibody (1)

    MED8 cDNA Clone (30)

    NM_201542.4

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_020000.3

    クローニングベクター cDNA 製品

    In lentiviral vector

    MED8 の背景知識

    Med8, a subunit of mediator complex, has proved to possess crucial functions in many organisms from yeast to human. Med8 protein is a regulator that specifically binds to upstream activating sequences (UASs) of SUC2 promoter, downstream repressing sequences (DRSs) of the HXK2 gene, and to the carboxy-terminal domain of the RNA polymerase II. In the plant, the med8 mutant of Arabidopsis thaliana displayed delayed anthesis and an increased number of leaves during the vegetative period. A loss-of-function mutation in the Mediator complex subunit 8 (MED8) causes small flowers as a result of reduced cell expansion. Analysis of the med8 med25-2 double mutant reveals that MED8 acts independently of MED25 to regulate cell expansion and organ growth. The MED8 subunit of the A. thaliana Mediator regulates plant immunity to B. cinerea through interacting with the transcription factor FAMA, which was discovered to be a key component in B. cinerea resistance.

    MED8 の参考文献

    • Xu R, et al. (2012) The mediator complex subunit 8 regulates organ size in arabidopsis thaliana. Plant Signal Behav 7 (2): 182-183.
    • Wang F, et al. (2011) Knockdown of ntmed8, a med8-like gene, causes abnormal development of vegetative and floral organs in tobacco (nicotiana tabacum l.). Plant Cell Rep 30 (11): 2117-2129.
    • Moreno-Herrero F, et al. (1999) Analysis by atomic force microscopy of med8 binding to cis-acting regulatory elements of the suc2 and hxk2 genes of saccharomyces cerevisiae. FEBS Lett 459 (3): 427-432.
    • Li X, et al. (2018) The arabidopsis thaliana mediator subunit med8 regulates plant immunity to botrytis cinerea through interacting with the basic helix-loop-helix (bhlh) transcription factor fama. PLoS One 13 (3): e0193458.

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