MED28 Antibodies, cDNA Clones Research Reagents

MED28 (Mediator Complex Subunit 28, also known as EG1; magicin; 1500003D12Rik), located on 4p15.32, is a Protein Coding gene. MED28 contains a motif for binding the SRC (190090) homology-2 (SH2) domain of GRB2 (108355) and several PxxP motifs for binding SH3 domains. It belongs to the Mediator complex subunit 28 family. MED28, a mammalian Mediator subunit, exhibits several cellular roles, including a merlin, Grb2, and cytoskeleton-associated protein (magicin), a repressor of smooth muscle cell differentiation, and an endothelial-derived gene (EG-1).

MED28 Antibody (1)

    MED28 cDNA Clone (30)

    BC011936

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_025895.4

    クローニングベクター cDNA 製品

    In lentiviral vector

    MED28 qPCR Primer (1)

    MED28 の背景知識

    MED28 (also known as EG-1 and magicin), a mammalian Mediator subunit, exhibits several cellular roles, including a merlin, Grb2, and cytoskeleton-associated protein (magicin), a repressor of smooth muscle cell differentiation, and an endothelial-derived gene (EG-1). Overexpression of MED28 may stimulate cell proliferation which presumably results from the transcriptional activation of the Mediator function. Additionally, several tumors, including breast cancer, highly express MED28. MED28 modulates the development of EMT through NFκB in human breast cancer cells, further reinforcing the significance of MED28 in the progression of breast cancer on top of its role in cell growth and migration. The mammalian mediator complex subunit 28 (MED28) regulates cell migration/invasion and epithelial-mesenchymal transition. MED28 has been implicated in transcriptional control, signal regulation, and cell proliferation.

    MED28 の参考文献

    • Yoon NK, et al. (2010) Elevated med28 expression predicts poor outcome in women with breast cancer. BMC Cancer 10 335.
    • Huang CY, et al. (2017) Med28 regulates epithelial-mesenchymal transition through nfκb in human breast cancer cells. J Cell Physiol 232 (6): 1337-1345.
    • Huang CY, et al. (2012) Med28 regulates mek1-dependent cellular migration in human breast cancer cells. J Cell Physiol 227 (12): 3820-3827.
    • Cho JG, et al. (2019) Med28 over-expression shortens the cell cycle and induces genomic instability. Int J Mol Sci 20 (7): 1746.

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