MED28 (also known as EG-1 and magicin), a mammalian Mediator subunit, exhibits several cellular roles, including a merlin, Grb2, and cytoskeleton-associated protein (magicin), a repressor of smooth muscle cell differentiation, and an endothelial-derived gene (EG-1). Overexpression of MED28 may stimulate cell proliferation which presumably results from the transcriptional activation of the Mediator function. Additionally, several tumors, including breast cancer, highly express MED28. MED28 modulates the development of EMT through NFκB in human breast cancer cells, further reinforcing the significance of MED28 in the progression of breast cancer on top of its role in cell growth and migration. The mammalian mediator complex subunit 28 (MED28) regulates cell migration/invasion and epithelial-mesenchymal transition. MED28 has been implicated in transcriptional control, signal regulation, and cell proliferation.