MDMX Proteins, Antibodies, cDNA Clones Research Reagents

MDM4 (MDM4 Regulator Of P53, also known as HDMX; MDMX; MRP1; BMFS6), located on 1q32.1, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. The gene produces a 54864 Da protein composed of 490 amino acids. The MDM4 gene encodes a protein that, along with MDM2, acts as a negative regulator of transcription factor TP53. The human MDM4 gene encodes a protein containing a RING finger domain and a putative nuclear localization signal. MDM4 is a key regulator of p53, whose biological activities depend on both transcriptional activity and transcription-independent mitochondrial functions.

MDMX Protein (1)

    MDMX Antibody (2)

      MDMX cDNA Clone (15)

      BC067299

      クローニングベクター cDNA 製品

      In lentiviral vector

      MDMX qPCR Primer (1)

      MDMX の背景知識

      MDM4 (MDM4 Regulator Of P53, also known as MDMX) is a Protein Coding gene. This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus and shows structural similarity to p53-binding protein MDM2. MDM4 is a promising target for cancer therapy, as it is undetectable in most normal adult tissues but often upregulated in cancer cells to dampen p53 tumor-suppressor function. MDM4, an essential negative regulator of the P53 tumor suppressor, is frequently overexpressed in cancer cells that harbor a wild-type P53. MDM4 is a key regulator of p53, whose biological activities depend on both transcriptional activity and transcription-independent mitochondrial functions. MDM4 binds to p53 and blocks its transcriptional activity.

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