MDM2 cDNA Clones Research Reagents

MDM2 (MDM2 Proto-Oncogene, also known as HDMX; LSKB; hdm2; ACTFS), located on 12q15, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. The gene produces a 55233 Da protein composed of 491 amino acids. MDM2 is an E3 ubiquitin ligase that targets the p53 protein for proteasomal degradation. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. It belongs to the MDM2/MDM4 family and is widely expressed in the colon, bone marrow, and other tissues.

MDM2 cDNA Clone (30)

NM_002392.3

クローニングベクター cDNA 製品

In lentiviral vector

NM_010786.3

クローニングベクター cDNA 製品

In lentiviral vector

MDM2 の背景知識

MDM2 (MDM2 Proto-Oncogene) is a Protein Coding gene. 11 alternatively spliced human isoforms have been reported. MDM2 gene encodes a nuclear-localized E3 ubiquitin ligase, which belongs to the MDM2/MDM4 family. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. It Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Overexpression or amplification of this locus is detected in a variety of different cancers. MDM2 is widely expressed in the colon, bone marrow, and other tissues. Diseases associated with MDM2 include Lessel-Kubisch Syndrome and Accelerated Tumor Formation.

MDM2 の参考文献

  • Zhuo X, Ye H, Li Q, Xiang Z, Zhang X. Is MDM2 SNP309 Variation a Risk Factor for Head and Neck Carcinoma?: An Updated Meta-Analysis Based on 11,552 Individuals. Langevin. S, ed. Medicine. 2016;95(9):e2948.

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