MDGA2 Proteins, cDNA Clones Research Reagents

MDGA2 (MAM Domain Containing Glycosylphosphatidylinositol Anchor 2, also known as MAMDC1; c14_5286), located on 14q21.3, is a Protein Coding gene. The gene produces a 107436 Da protein composed of 956 amino acids. The protein contains 6 Ig repeats and a highly conserved MAM domain but lacks the fibronectin III domain found in MDGA1. Diseases such as Ring Dermoid Of Cornea and Autism are associated with MDGA2. The related pathways of MDGA2 include the Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins.

MDGA2 Protein (1)

    MDGA2 cDNA Clone (26)

    NM_001113498.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_207010.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    MDGA2 Lysate (1)

      MDGA2 の背景知識

      MAM domain-containing glycosylphosphatidylinositol anchor protein 2, also known as MAM domain-containing protein 1, MDGA2, and MAMDC1, is a cell membrane protein that contains six Ig-like (immunoglobulin-like) domains and one MAM domain. Analyses of the full-length coding region of MDGA1 and MDGA2 indicate that they encode proteins that comprise a novel subgroup of the Ig superfamily and have a unique structural organization consisting of six immunoglobulin (Ig)-like domains followed by a single MAM domain. Biochemical characterization demonstrates that MDGA1 and MDGA2 proteins are highly glycosylated and that MDGA1 is tethered to the cell membrane by a GPI anchor. The MDGAs are differentially expressed by subpopulations of neurons in both the central and peripheral nervous systems, including neurons of the basilar pons, inferior olive, cerebellum, cerebral cortex, olfactory bulb, spinal cord, and dorsal root and trigeminal ganglia. The similarity of MDGAs to other Ig-containing molecules and their temporal-spatial patterns of expression within restricted neuronal populations, for example migrating pontine neurons and D1 spinal interneurons, suggest a role for these novel proteins in regulating neuronal migration, as well as other aspects of neural development, including axon guidance.

      MDGA2 の参考文献

      • Litwack,ED. et al., 2004, Mol Cell Neurosci. 25 (2): 263-74.
      • Hellquist, A. et al., 2009, PLoS One. 4 (12): e8037.
      • Sano,S. et al., 2009, Genesis. 47 (8):505-13.
      • Bucan, M. et al., 2009, PLoS Genet. 5 (6):e1000536.

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