MD2/LY96 Proteins, cDNA Clones Research Reagents

LY96 (Lymphocyte Antigen 96, also known as MD2; MD-2; ly-96; ESOP-1), located on 8q21.11, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat. The gene produces a 18546 Da protein composed of 160 amino acids. This gene encodes a protein that associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccharide (LPS), thus providing a link between the receptor and LPS signaling. Diseases such as Melioidosis and Intestinal Botulism are associated with LY96. The related pathways of LY96 include Antigen processing-Cross presentation and Activated TLR4 signaling.

MD2/LY96 Protein (1)

    MD2/LY96 cDNA Clone (26)

    NM_015364.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_016923.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    MD2/LY96 Lysate (1)

      MD2/LY96 の背景知識

      LY96 (Lymphocyte Antigen 96, also known as ESOP-1) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. This gene encodes a protein that associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccharide (LPS), thus providing a link between the receptor and LPS signaling. LY-96 also cooperates with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. It enhances the TLR4-dependent activation of NF-kappa-B. ESOP-1 has 16 amino acids, the sequence of which shows 64% identity with human ESOP-1/MD-2. ESOP-1 mRNA is highly expressed in the mouse embryos at 7.5 days after coitus. Diseases associated with LY96 include Melioidosis and Intestinal Botulism.

      MD2/LY96 の参考文献

      • Shimazu R., et al.,(1999), MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J. Exp. Med. 189:1777-1782.
      • Kato K., et al., (2000), ESOP-1, a secreted protein expressed in the hematopoietic, nervous, and reproductive systems of embryonic and adult mice.Blood 96:362-364.
      • Schromm A.B., et al.,(2001), Molecular genetic analysis of an endotoxin nonresponder mutant cell line. A point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling.J. Exp. Med. 194:79-88.

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