MD1 Proteins, Antibodies, cDNA Clones Research Reagents

LY86 (Lymphocyte Antigen 86, also known as MD1; MD-1; MMD-1; dJ80N2.1), located on 6p25.1, is a Protein Coding gene. The gene produces a 17906 Da protein composed of 162 amino acids. The MD1 protein shares 66% amino acid identity with mouse Md1 and has a predicted 19-amino acid signal peptide and 2 N-glycosylation sites. Six of 7 cysteine residues in human MD1 are conserved in mouse and chicken Md1. Diseases such as Muscular Dystrophy, Duchenne Type, and Common Bile Duct Neoplasm are associated with LY86. The related pathways of LY86 include Activated TLR4 signaling and the Innate Immune System.

MD1 Protein (2)

    MD1 Antibody (3)

      MD1 cDNA Clone (26)

      NM_004271.3.

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_010745.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      MD1 Lysate (2)

        MD1 の背景知識

        MD-1 and MD-2 are secretory glycoproteins that exist on the cell surface in complexes with transmembrane proteins. MD-1 is anchored by radioprotective 15 (RP15) which is a molecule containing leucine-rich repeats and is expressed on B cells, dendritic cells, and macrophages, while MD-2 is associated with TLR4. MD-1 is required for efficient RP15 cell surface expression and function. It is indicated that the RP15/MD1 complex, in conjunction with TLR4, mediates the innate immune response to LPS in B cells, and also plays a role in protecting against apoptosis, B-cell proliferation, etc. Mouse MD-1 cDNA encodes a 162 amino acid precursor protein with a putative 19 aa signal peptide and two potential N-linked glycosylation sites. It shares 4% and 66% amino acid sequence identity with chicken and human MD-1 respectively. MD-1 is mainly expressed in the spleen, and also detectable in the liver, brain, thymus, and kidney.

        MD1 の参考文献

        • Miura Y., et al.,(1998), RP105 is associated with MD-1 and transmits an activation signal in human B cells. Blood 92:2815-2822.
        • Begum N.A., et al., (1999), Human MD-1 homologue is a BCG-regulated gene product in monocytes: Its identification by differential display.Biochem. Biophys. Res. Commun. 256:325-329.
        • Mungall A.J., et al.,(2003), The DNA sequence and analysis of human chromosome 6.Nature 425:805-811.

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