MCTP2 Antibodies, cDNA Clones Research Reagents

MCTP2 (Multiple C2 And Transmembrane Domain Containing 2), located on 15q26.2, is a Protein Coding gene. The encoded protein might play a role in the development of the cardiac outflow tract. It belongs to the MCTP family. The full-length 878-amino acid MCTP2 protein has 3 C2 domains, 2 transmembrane domains, and a short cytoplasmic C-terminal tail that includes a 12-residue stretch that is identical in all species and isoforms. All MCTP C2 domains except for the second C2 domain of MCTP2 include a perfect Ca2+/phospholipid-binding consensus sequence.

MCTP2 Antibody (1)

    MCTP2 cDNA Clone (15)

    NM_018349.3

    クローニングベクター cDNA 製品

    In lentiviral vector

    BC025708

    クローニングベクター cDNA 製品

    In lentiviral vector

    MCTP2 qPCR Primer (1)

    MCTP2 の背景知識

    The invertebrate organisms Caenorhabditis elegans and Drosophila melanogaster express a single MCTP gene, whereas vertebrates express two MCTP genes (MCTP1 and MCTP2) whose primary transcripts are extensively alternatively spliced. Most of the MCTP sequences, in particular the C2 domains, are highly conserved. All MCTP C2 domains except for the second C2 domain of MCTP2 include a perfect Ca2+/phospholipid-binding consensus sequence. In higher eukaryotes, multiple C2 domain-containing transmembrane protein (MCTP2) is similar to Pex30: it contains an RHD and resides in ER domains where most nascent LD biogenesis occurs and that often associate with peroxisomes. The MCTP2 gene, located on chromosome 15q26, influences adiposity. The MCTP2 gene is involved in intercellular signal transduction and synapse function. MCTP2 is also a novel genetic cause of CoA and related cardiac malformations.

    MCTP2 の参考文献

    • Shin OH, et al. (2005) Evolutionarily conserved multiple c2 domain proteins with two transmembrane regions (mctps) and unusual ca2+ binding properties. J Biol Chem 280 (2): 1641-1651.
    • Lalani SR, et al. (2013) Mctp2 is a dosage-sensitive gene required for cardiac outflow tract development. Hum Mol Genet 22 (21): 4339-4348.
    • Joshi AS, et al. (2018) Lipid droplet and peroxisome biogenesis occur at the same er subdomains. Nat Commun 9 (1): 2940.
    • Djurovic S, et al. (2009) Association of mctp2 gene variants with schizophrenia in three independent samples of scandinavian origin (scope). Psychiatry Res 168 (3): 256-258.

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