MCM8 (Minichromosome Maintenance 8 Homologous Recombination Repair Factor, also known as POF10 and C20orf154) is a Protein Coding gene. The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. MCM8 is a new family member, not present in yeast, which may function alone or with other family members in aspects of DNA metabolism, including replication initiation and elongation. MCM8, a component of the pre-replication complex, is crucial for gonadal development and maintenance in humans-both males and females. MCM8 is broadly expressed in the testis, lymph node, and other tissues. Diseases associated with MCM8 include Premature Ovarian Failure 10 and Amenorrhea.