MCFD2 Antibodies, cDNA Clones Research Reagents

MCFD2 (Multiple Coagulation Factor Deficiency 2, ER Cargo Receptor Complex Subunit, also known as F5F8D; SDNSF; F5F8D2; LMAN1IP), located on 2p21, is a Protein Coding gene. This gene encodes a soluble luminal protein with two calmodulin-like EF-hand motifs at its C-terminus. Human MCFD2 is a 16-kDa protein known to participate in the transport of the glycosylated human coagulation factors V and VIII along the secretory pathway. The MCFD2-LMAN1 (lectin mannose-binding protein 1; also known as ERGIC-53) complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins.

MCFD2 Antibody (1)

    MCFD2 cDNA Clone (28)

    BC040357

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_176808.5

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_139253.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    MCFD2 の背景知識

    Human MCFD2 (multiple coagulation factor deficiency 2) is a 16-kDa protein known to participate in the transport of the glycosylated human coagulation factors V and VIII along the secretory pathway. MCFD2, a binding partner of lectin mannose-binding 1 (LMAN1), causes combined deficiencies of coagulation factors V and VIII. MCFD2 promotes cancer metastasis by regulating LMAN1 and LGALS3BP expression levels. Hence, MCFD2 may represent a promising candidate for a novel therapeutic target for patients with metastatic OSCCs. MCFD2 is an EF-hand domain protein that forms a calcium-dependent heteromeric complex with LMAN1 in cells. Missense mutations in the EF-hand domains of MCFD2 abolish the interaction with LMAN1. The LMAN1-MCFD2 complex may serve as a cargo receptor for the ER-to-Golgi transport of FV and FVIII, and perhaps some other glycoproteins. The B domain of FVIII may be important in mediating its interaction with the LMAN1-MCFD2 complex.

    MCFD2 の参考文献

    • Zhang B (2009) Recent developments in the understanding of the combined deficiency of fv and fviii. Br J Haematol 145 (1): 15-23.
    • Guy JE, et al. (2008) New insights into multiple coagulation factor deficiency from the solution structure of human mcfd2. J Mol Biol 381 (4): 941-955.
    • Fukamachi M, et al. (2018) Multiple coagulation factor deficiency protein 2 as a crucial component in metastasis of human oral cancer. Exp Cell Res 368 (1): 119-125.

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