MASTL/THC2 Antibodies, cDNA Clones Research Reagents

MASTL (Microtubule Associated Serine/Threonine Kinase Like, also known as GW; GWL; THC2; MAST-L; GREATWALL), located on 10p12.1, is a Protein Coding gene. This gene encodes a microtubule-associated serine/threonine kinase that inhibits protein phosphatase-2 (PP2A)-B55 complexes during mitosis. It belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family. MASTL kinase is a master regulator of mitosis, essential for ensuring that mitotic substrate phosphorylation is correctly maintained. Loss of MASTL causes chromosome segregation errors, mitotic collapse, and failure of cytokinesis.

MASTL/THC2 Antibody (1)

    MASTL/THC2 cDNA Clone (30)

    NM_032844.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_025979.4

    クローニングベクター cDNA 製品

    In lentiviral vector

    MASTL/THC2 の背景知識

    Microtubule-associated serine/threonine kinase-like (MASTL) is the functional mammalian ortholog of Greatwall kinase (Gwl), which was originally discovered in Drosophila. The human MASTL (Microtubule-associated serine/threonine kinase-like) gene encodes an essential protein in the cell cycle. MASTL is a key factor preventing early dephosphorylation of M-phase targets of Cdk1/CycB. MASTL kinase is a master regulator of mitosis, essential for ensuring that mitotic substrate phosphorylation is correctly maintained. MASTL controls the final G2/M checkpoint and prevents premature entry of cells into mitosis. Loss of MASTL causes chromosome segregation errors, mitotic collapse, and failure of cytokinesis. However, in cancer MASTL is most commonly amplified and overexpressed. This correlates with increased chromosome instability in breast cancer and poor patient survival in breast, ovarian, and lung cancer. MASTL kinase promotes mitotic progression and cell cycle reentry after DNA damage.

    MASTL/THC2 の参考文献

    • Uppada SB, et al. (2018) Mastl induces colon cancer progression and chemoresistance by promoting wnt/β-catenin signaling. Mol Cancer 17 (1): 111.
    • Rogers S, et al. (2018) Mastl overexpression promotes chromosome instability and metastasis in breast cancer. Oncogene 37 (33): 4518-4533.
    • Marzec K, et al. (2018) The oncogenic functions of mastl kinase. Front Cell Dev Biol 6 162.
    • Hermida D, et al. (2020) Molecular basis of the mechanisms controlling mastl. Mol Cell Proteomics 19 (2): 326-343.

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