MARCO Proteins, cDNA Clones Research Reagents

MARCO (Macrophage Receptor With Collagenous Structure, also known as SR-A6; SCARA2), located on 2q14.2, is conserved in chimpanzee, Rhesus monkey, dog, mouse, rat, chicken, zebrafish, and frog. The gene produces a 52658 Da protein composed of 520 amino acids. The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. Diseases such as Igg4-Related Disease and Bacterial Pneumonia are associated with MARCO. The related pathways of MARCO include A-beta Uptake and Degradation and Binding and Uptake of Ligands by Scavenger Receptors.

MARCO Protein (1)

    MARCO cDNA Clone (13)

    NM_010766.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    MARCO qPCR Primer (1)

    MARCO Lysate (1)

      MARCO の背景知識

      Macrophage receptor MARCO, also known as Macrophage receptor with collagenous structure and Marco, is a single-pass type II membrane protein. MARCO is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. It is expressed in subpopulations of macrophages in the spleen and the medullary cord of lymph nodes. Although it is expressed on subsets of macrophages, it can be upregulated on other macrophages after bacterial infection. The strategic position of MARCO-expressing cells in lymphoid organs suggests an important role for this bacteria-binding molecule in the removal of pathogens. MARCO has a short N-terminal cytoplasmic domain, a transmembrane domain, and a large extracellular part composed of a 75-residue long spacer domain, a 27-residue collagenous domain, and a 99-residue long scavenger receptor cysteine-rich (SRCR) domain. It is possible that cooperation between the SRCR domain and the collagenous domain is needed for high-affinity bacterial binding, or that the SRCR domain has to be in a trimeric form to effectively bind to bacteria

      MARCO の参考文献

      • Kraal, G. et al., 2000, Microbes Infect . 2 (3): 313-6.
      • Sankala, M., 2002, J Biol Chem. 277 (36): 33378-85.
      • Arredouani, MS., 2004, Cell Mol Biol. 50 Online Pub : OL657-65.
      • Thakur, SA., 2009, Toxicol Sci. 107 (1): 238-46.

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