MAP7 Antibodies, cDNA Clones Research Reagents

MAP7 (Microtubule Associated Protein 7, also known as EMAP115; E-MAP-115), located on 6q23.3, is a Protein Coding gene. The product of this gene is a microtubule-associated protein that is predominantly expressed in cells of epithelial origin. It belongs to the MAP7 family. MAP7 is a ubiquitous microtubule-associated protein (MAP) that organizes the microtubule cytoskeleton in mitosis and neuronal branching. MAP7 is a retinoic acid-inducible gene expressed in cells of epithelial origin and implicated in microtubule functions required for spermatogenesis.

MAP7 Antibody (1)

    MAP7 cDNA Clone (15)

    BC025777

    クローニングベクター cDNA 製品

    In lentiviral vector

    MAP7 qPCR Primer (1)

    MAP7 の背景知識

    MAP7 (ensconsin, E-MAP-115) is a ubiquitous MAP that organizes the microtubule cytoskeleton in mitosis and neuronal branching. Microtubule-associated protein MAP7 (ensconsin in Drosophila) is an essential kinesin-1 cofactor and promotes kinesin-1 recruitment to microtubules. MAP7 is a unique microtubule-associated protein that interacts with both microtubules and the motor protein kinesin-1. Structure-function analysis in rat embryonic sensory neurons shows that the kinesin-1 interacting domain in MAP7 is required for axon and branch growth but not for branch formation. Also, two unique microtubule-binding sites are found in MAP7 that have distinct dissociation kinetics and are both required for branch formation. Furthermore, MAP7 recruits kinesin-1 dynamically to microtubules, leading to alterations in organelle transport behaviors, particularly pause/speed switching. Microtubule-associated protein 7 (MAP7) plays an important role in cancer cells.

    MAP7 の参考文献

    • Tymanskyj SR, et al. (2018) Map7 regulates axon morphogenesis by recruiting kinesin-1 to microtubules and modulating organelle transport. Elife 7: e36374.
    • Pan X, et al. (2019) Map7d2 localizes to the proximal axon and locally promotes kinesin-1-mediated cargo transport into the axon. Cell Rep 26 (8): 1988-1999.e1986.
    • Chaudhary AR, et al. (2019) Map7 regulates organelle transport by recruiting kinesin-1 to microtubules. J Biol Chem 294 (26): 10160-10171.

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