MAP4K5 Proteins Research Reagents

MAP4K5 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 5, also known as KHS; GCKR; KHS1; MAPKKKK5), located on 14q22.1, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. The gene produces a 95024 Da protein composed of 846 amino acids. This gene encodes a member of the serine/threonine-protein kinase family, which is highly similar to yeast SPS1/STE20 kinase. Diseases such as Spastic Paraplegia 3A and Septal Myocardial Infarction are associated with MAP4K5. The related pathways of MAP4K5 include the Signal transduction_JNK pathway and TRAF Pathway.

MAP4K5 Protein (1)

    MAP4K5 Lysate (1)

      MAP4K5 の背景知識

      Mitogen-activated protein kinase kinase kinase kinase 5, also known as Kinase homologous to SPS1/STE2, MAPK/ERK kinase kinase kinase 5, MEK kinase kinase 5, and MAP4K5, is a cytoplasm protein that belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family and STE2 subfamily. MAP4K5 is ubiquitously expressed in all tissues examined, with high levels in the ovary, testis, and prostate. It contains one CNH domain and one protein kinase domain. MAP4K5 is highly similar to yeast SPS1/STE2 kinase. Yeast SPS1/STE2 functions near the beginning of the MAP kinase signal cascades that are essential for yeast pheromone response. MAP4K5 has been shown to interact with CRKL and TRAF2. This kinase was shown to activate Jun kinase in mammalian cells. MAP4K5 is an early component of MAP kinase signal cascades. It may play a role in the response to environmental stress. MAP4K5 appears to act upstream of the JUN N-terminal pathway.

      MAP4K5 の参考文献

      • Schultz SJ, et al.,1994, Cell Growth Differ. 4 (10): 821-30.
      • Tung RM, et al.,1997, Oncogene 14 (6): 653-9.
      • Shi, C S, et al., 1999, J. Immunol.163 (6): 3279-85.
      • Shi, C S, et al., 2000, Blood. 95 (3): 776-82. 
      • Gu,Y. et al., 2006, J Hum Genet  51 (7): 605-10. 

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